Hydropericardium syndrome caused by fowl adenovirus serotype 4 in replacement pullets

Hydropericardium syndrome (HPS) is one of the important emerging diseases causing huge losses to the poultry industry. It affects mainly 3- to 6-week-old broiler chickens and rarely occurs in breeding and laying flocks. Recently, an HPS case was recorded with a sudden heavy mortality in a 100-day-ol...

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Bibliographic Details
Published inJournal of Veterinary Medical Science Vol. 81; no. 2; pp. 245 - 251
Main Authors CHEN, Zhen, SHI, Shaohua, QI, Baoming, LIN, Su, CHEN, Cuiteng, ZHU, Chunhua, HUANG, Yu
Format Journal Article
LanguageEnglish
Published Japan JAPANESE SOCIETY OF VETERINARY SCIENCE 2019
Japan Science and Technology Agency
The Japanese Society of Veterinary Science
Subjects
Adenoviruses
Comparative analysis
Electron microscopy
fowl adenovirus serotype 4
Genomes
hydropericardium syndrome
Inclusion bodies
Mortality
Nucleotide sequence
Open reading frames
Phylogeny
Polymerase chain reaction
Poultry
replacement pullet
Virology
hydropericardium syndrome
replacement pullet
fowl adenovirus serotype 4
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Summary:Hydropericardium syndrome (HPS) is one of the important emerging diseases causing huge losses to the poultry industry. It affects mainly 3- to 6-week-old broiler chickens and rarely occurs in breeding and laying flocks. Recently, an HPS case was recorded with a sudden heavy mortality in a 100-day-old laying flock. A fowl adenovirus serotype 4 (FAdV-4), named as GDMZ strain, was isolated and identified using polymerase chain reaction coupled with electron microscopy. The animal experiment showed that a mortality of 100% was recorded with hydropericardium as a conspicuous lesion throughout the course of infection. Microscopically, vacuolar changes and intranuclear inclusion bodies were observed in the liver and vacuolar changes were observed in the heart. The complete genome sequence of GDMZ strain was determined to investigate the molecular properties of GDMZ strain. The comparative analysis revealed that the novel Chinese FAdV-4 isolate contained open reading frame (ORF) 19, ORF27, and ORF48 genomic deletions. The phylogenetic analysis revealed that FAdV-4 could be divided into two major clades, of which Chinese FAdV-4 were located at a distinct clade.
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These authors contributed equally to this work.
ISSN:0916-7250
1347-7439
1347-7439
DOI:10.1292/jvms.18-0168