Triterpenoidal Saponins from the Barks of Zygophyllum fabago L

• Published in: Chemical & Pharmaceutical Bulletin Vol. 56; no. 6; pp. 858 - 860
• Main Authors: Feng, Yu-Lin, Wu, Bei, Li, He-Ran, Li, Yun-Qiu, Xu, Li-Zhen, Yang, Shi-Lin, Kitanaka, Susumu
• Format: Journal Article
• Language: English; Japanese
• Published: TOKYO The Pharmaceutical Society of Japan 01.06.2008; Pharmaceutical Society of Japan; Pharmaceutical Soc Japan; Japan Science and Technology Agency
• Subjects: Animals; Cell Line; Chemistry; Chemistry, Medicinal; Chemistry, Multidisciplinary; Hydrolysis; Life Sciences & Biomedicine; Macrophages - metabolism; Magnetic Resonance Spectroscopy; Mice; Molecular Conformation; nitric oxide; Nitric Oxide - antagonists & inhibitors; Nitric Oxide - biosynthesis; Pharmacology & Pharmacy; Physical Sciences; Plant Bark - chemistry; Plant Extracts - chemistry; Saponins - isolation & purification; Science & Technology; Spectrometry, Mass, Electrospray Ionization; Spectrophotometry, Infrared; Tetrazolium Salts; Thiazoles; Triterpenes - isolation & purification; triterpenoid saponin; Zygophyllum - chemistry; Zygophyllum fabago L; zygophyloside O; zygophyloside P; nitric oxide; triterpenoid saponin; Zygophyllum fabago L; sygophyloside P; zygophyloside O
• ISSN: 0009-2363; 1347-5223
• DOI: 10.1248/cpb.56.858

Two new triterpenoid saponins, zygophylosides O (1) and P (2), have been isolated from the barks of Zygophyllum fabago L. Their structures were elucidated as 3β-[(2-O-sulfo-β-D-xylopyranosyl)oxy]urs-12-ene-27,28-dioic acid and 3β-[(2-O-sulfo-β-D-xylopyranosyl)oxy]urs-12-ene-27,28-dioic acid 28-β-D-glucopyranoside, respectively, by spectral and chemical evidence. Compound 1 showed weaker Nitric Oxide (NO) inhibitory activity.