Serum Levels of the Adipokine Chemerin in Relation to Renal Function

• Published in: Diabetes care Vol. 33; no. 1; pp. 171 - 173
• Main Authors: Pfau, Dörte, Bachmann, Anette, Lössner, Ulrike, Kratzsch, Jürgen, Blüher, Matthias, Stumvoll, Michael, Fasshauer, Mathias
• Format: Journal Article
• Language: English
• Published: Alexandria, VA American Diabetes Association 01.01.2010
• Subjects: Aged; Aged, 80 and over; Biological and medical sciences; Cardiovascular disease; Chemokines - metabolism; Dextrose; Diabetes; Diabetes. Impaired glucose tolerance; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; Enzyme-Linked Immunosorbent Assay; Female; Glomerular Filtration Rate; Glucose; Glucose metabolism; Humans; Intercellular Signaling Peptides and Proteins; Kidney - metabolism; Kidney Function Tests; Male; Medical research; Medical sciences; Medicine, Experimental; Metabolic diseases; Metabolic syndrome; Middle Aged; Miscellaneous; Multivariate analysis; Original Research; Physiological aspects; Public health. Hygiene; Public health. Hygiene-occupational medicine; Regression analysis; Renal Dialysis; Sample size; Studies; Human; Kidney disease; Chemerin; Urinary system disease; Renal function; Nutrition; Clinical biology; Metabolic diseases; Adipokine; Endocrinology
• ISSN: 0149-5992; 1935-5548
• DOI: 10.2337/dc09-1351

OBJECTIVE: To investigate serum levels of the adipokine chemerin in patients on chronic hemodialysis (CD) as compared with control patients with a glomerular filtration rate (GFR) >50 ml/min. RESEARCH DESIGN AND METHODS: Chemerin was quantified by ELISA in control patients (n = 60) and CD patients (n = 60) and correlated with clinical and biochemical measures of renal function, glucose, and lipid metabolism, as well as inflammation, in both groups. RESULTS: Median serum chemerin levels were more than twofold higher in CD patients (542.2 μg/l) compared with subjects with a GFR >50 ml/min (254.3 μg/l) (P < 0.001). Furthermore, GFR, as assessed by the original Modification of Diet in Renal Disease formula, independently predicted circulating chemerin concentrations in multiple regression analyses in both control patients (P < 0.05) and CD patients (P < 0.01). CONCLUSIONS: We demonstrate that markers of renal function are independently related to circulating chemerin levels.