Antidiabetic, Antioxidant and Antihyperlipidemic Status of Heliotropium zeylanicum Extract on Streptozotocin-Induced Diabetes in Rats

• Published in: Biological & Pharmaceutical Bulletin Vol. 29; no. 11; pp. 2202 - 2205
• Main Authors: Murugesh, Kandasamy, Yeligar, Veerendra, Dash, Deepak Kumar, Sengupta, Pinaki, Maiti, Bhim Chandra, Maity, Tapan Kumar
• Format: Journal Article
• Language: English
• Published: Japan The Pharmaceutical Society of Japan 01.11.2006; Pharmaceutical Society of Japan; Japan Science and Technology Agency
• Subjects: Administration, Oral; Animals; antihyperglycemic activity; antihyperlipidemic effect; antioxidant potential; Antioxidants - administration & dosage; Antioxidants - isolation & purification; Antioxidants - therapeutic use; Blood Glucose - analysis; Body Weight - drug effects; Catalase - metabolism; Diabetes Mellitus, Experimental - chemically induced; Diabetes Mellitus, Experimental - metabolism; Diabetes Mellitus, Experimental - prevention & control; Drinking - drug effects; Eating - drug effects; Glutathione - metabolism; Heliotropium - chemistry; Heliotropium zeylanicum; Hypercholesterolemia - chemically induced; Hypercholesterolemia - metabolism; Hypercholesterolemia - prevention & control; Hypertriglyceridemia - chemically induced; Hypertriglyceridemia - metabolism; Hypertriglyceridemia - prevention & control; Hypoglycemic Agents - administration & dosage; Hypoglycemic Agents - isolation & purification; Hypoglycemic Agents - therapeutic use; Hypolipidemic Agents - administration & dosage; Hypolipidemic Agents - isolation & purification; Hypolipidemic Agents - therapeutic use; Liver - drug effects; Liver - metabolism; Male; Phytotherapy - methods; Plant Extracts - administration & dosage; Plant Extracts - chemistry; Plant Extracts - therapeutic use; Rats; Rats, Wistar; Streptozocin; streptozotocin-induced diabetic rat; Superoxide Dismutase - metabolism; Thiobarbituric Acid Reactive Substances - metabolism; Tolbutamide - pharmacology
• ISSN: 0918-6158; 1347-5215
• DOI: 10.1248/bpb.29.2202

The potential role of the methanolic extract of Heliotropium zeylanicum (BURM.F) LAMK (MEHZ) in the treatment of diabetes along with its antioxidant and antihyperlipidemic effects was studied in streptozotocin-induced diabetic rats. Oral administration of (MEHZ) 150 and 300 mg/kg/d for 14 d significantly decreased the blood glucose level and considerably increased the body weight, food intake, and liquid intake of diabetic-induced rats. MEHZ significantly decreased thiobarbituric acid reactive substances and significantly increased reduced glutathione, superoxide dismutase and catalase in streptozotocin-induced diabetic rats at the end of 14 d of treatment. The study also investigated the antihyperlipidemic potential of MEHZ. The results show that the active fraction of MEHZ is promising for development of a standardized phytomedicine for the treatment of diabetes mellitus.