Genome Sequence of “Candidatus Methanomethylophilus alvus” Mx1201, a Methanogenic Archaeon from the Human Gut Belonging to a Seventh Order of Methanogens

• Published in: Journal of Bacteriology Vol. 194; no. 24; pp. 6944 - 6945
• Main Authors: Borrel, Guillaume, Harris, Hugh M. B, Tottey, William, Mihajlovski, Agnès, Parisot, Nicolas, Peyretaillade, Eric, Peyret, Pierre, Gribaldo, Simonetta, O'Toole, Paul W, Brugère, Jean-François
• Format: Journal Article
• Language: English
• Published: Washington, DC American Society for Microbiology 01.12.2012
• Subjects: Aged; Aged, 80 and over; anaerobic conditions; Anaerobiosis; Archaea - classification; Archaea - genetics; Archaea - isolation & purification; Archaea - metabolism; Bacteria; Bacteriology; Biochemistry; Biochemistry, Molecular Biology; Biodiversity; Biological and medical sciences; Biotechnology; Cardiology and cardiovascular system; Cell Behavior; Cellular Biology; digestive system; DNA, Archaeal - genetics; Ecology, environment; Ecosystems; feces; Feces - microbiology; Food and Nutrition; Fundamental and applied biological sciences. Psychology; Gastrointestinal Tract - microbiology; Genes; Genome Announcements; Genome, Archaeal; Genomes; Genomics; Health; Human health and pathology; Humans; Hépatology and Gastroenterology; Life Sciences; methane production; methanogens; Methanol; Methanol - metabolism; Methyltransferases - genetics; Microbiology; Microbiology and Parasitology; Miscellaneous; Molecular biology; Molecular Sequence Data; nucleotide sequences; Populations and Evolution; RNA, Ribosomal, 16S - genetics; RNA, Ribosomal, 23S - genetics; Sequence Analysis, DNA; Subcellular Processes; Substrates; Symbiosis; Systematics, Phylogenetics and taxonomy; Human; Bacteria; Nucleotide sequence; Digestive system; Archaeobacteria; Gut
• ISSN: 0021-9193; 1098-5530; 1067-8832
• DOI: 10.1128/jb.01867-12

We report the draft genome sequence of “Candidatus Methanomethylophilus alvus” Mx1201, a methanogen present in the human gut. It was enriched from human feces under anaerobic conditions with methanol as the substrate. Its circular genome, of around 1.7 Mb, contains genes needed for methylotrophic methanogenesis from methanol and tri-, di-, and monomethylamine.