Differential Shedding and Antibody Kinetics of Zika and Chikungunya Viruses, Brazil

• Published in: Emerging infectious diseases Vol. 25; no. 2; pp. 311 - 315
• Main Authors: Bozza, Fernando A, Moreira-Soto, Andres, Rockstroh, Alexandra, Fischer, Carlo, Nascimento, Alessandra D, Calheiros, Andrea S, Drosten, Christian, Bozza, Patrícia T, Souza, Thiago Moreno L, Ulbert, Sebastian, Drexler, Jan Felix
• Format: Journal Article
• Language: English
• Published: United States U.S. National Center for Infectious Diseases 01.02.2019; Centers for Disease Control and Prevention
• Subjects: Adult; Antibodies; Antibodies, Viral - immunology; Antigens; Brazil - epidemiology; Chikungunya Fever - diagnosis; Chikungunya Fever - epidemiology; Chikungunya Fever - immunology; Chikungunya Fever - virology; chikungunya virus; Chikungunya virus - physiology; Dengue virus; diagnosis; Differential Shedding and Antibody Kinetics of Zika and Chikungunya Viruses, Brazil; Dispatch; Female; Health aspects; Humans; Immune response; Immunoassay; Infection; Male; Medical tests; Recurrence (Disease); RT-PCR; serology; Virus Shedding; viruses; Zika virus; Zika Virus - physiology; Zika Virus Infection - diagnosis; Zika Virus Infection - epidemiology; Zika Virus Infection - immunology; Zika Virus Infection - virology; Brazil; Latin America; viruses; vector-borne infections; arboviruses; serology; Brazil; diagnosis; Zika virus; flaviviruses; real time RT-PCR; chikungunya virus
• ISSN: 1080-6040; 1080-6059
• DOI: 10.3201/eid2502.180166

In seroconversion panels obtained from patients from Brazil, diagnostic testing for Zika virus infection was improved by combining multiple antibody isotypes, techniques, and antigens, but sensitivity remained suboptimal. In contrast, chikungunya virus diagnostic testing was unambiguous. Recurrent recent arbovirus infections suggested by serologic data and unspecific symptoms highlight the need for exhaustive virologic testing.