Treatment Failure of Dihydroartemisinin/Piperaquine for Plasmodium falciparum Malaria, Vietnam

• Published in: Emerging infectious diseases Vol. 23; no. 4; pp. 715 - 717
• Main Authors: Phuc, Bui Quang, Rasmussen, Charlotte, Duong, Tran Thanh, Dong, Le Than, Loi, Mai Anh, Ménard, Didier, Tarning, Joel, Bustos, Dorina, Ringwald, Pascal, Galappaththy, Gawrie Loku, Thieu, Nguyen Quang
• Format: Journal Article
• Language: English
• Published: United States U.S. National Center for Infectious Diseases 01.04.2017; Centers for Disease Control and Prevention
• Subjects: Adolescent; Adult; Antimalarials - administration & dosage; Antimalarials - therapeutic use; artemisinin; Artemisinins - administration & dosage; Artemisinins - therapeutic use; Care and treatment; dihydroartemisinin-piperaquine; Drug Combinations; Drug Resistance; Female; Humans; Malaria; Malaria, Falciparum - drug therapy; Malaria, Falciparum - epidemiology; Malaria, Vietnam; Male; Medical research; Middle Aged; Mutation; Plasmodium falciparum; Plasmodium falciparum - genetics; Protozoan Proteins - genetics; Protozoan Proteins - metabolism; Quinolines - administration & dosage; Quinolines - therapeutic use; Research Letter; Treatment Failure of Dihydroartemisinin/Piperaquine for; Vietnam; Vietnam - epidemiology; Cambodia; Vietnam; artemisinin; Plasmodium falciparum; Vietnam; dihydroartemisinin/piperaquine; vector-borne infections; antimicrobial resistance; drug resistance; malaria; mefloquine; piperaquine
• ISSN: 1080-6040; 1080-6059
• DOI: 10.3201/eid2304.161872

We conducted a study in Binh Phuoc, Vietnam, in 2015 on the therapeutic efficacy of dihydroartemisinin/piperaquine for Plasmodium falciparum malaria. A high number of treatment failures (14/40) was found, and piperaquine resistance in Vietnam was confirmed. A change in the malaria treatment policy for Vietnam is in process.