A Controlled Trial of Sustained-Release Bupropion, a Nicotine Patch, or Both for Smoking Cessation

• Published in: The New England journal of medicine Vol. 340; no. 9; pp. 685 - 691
• Main Authors: Jorenby, Douglas E, Leischow, Scott J, Nides, Mitchell A, Rennard, Stephen I, Johnston, J. Andrew, Hughes, Arlene R, Smith, Stevens S, Muramoto, Myra L, Daughton, David M, Doan, Kimberli, Fiore, Michael C, Baker, Timothy B
• Format: Journal Article
• Language: English
• Published: Boston, MA Massachusetts Medical Society 04.03.1999
• Subjects: Administration, Cutaneous; Adult; Antidepressive Agents, Second-Generation - adverse effects; Antidepressive Agents, Second-Generation - therapeutic use; Biological and medical sciences; Bupropion - adverse effects; Bupropion - therapeutic use; Delayed-Action Preparations; Drug therapy; Drug Therapy, Combination; Female; Humans; Male; Medical research; Medical sciences; Nicotine - adverse effects; Nicotine - therapeutic use; Smoking cessation; Smoking Cessation - methods; Smoking Cessation - psychology; Smoking Cessation - statistics & numerical data; Substance Withdrawal Syndrome; Tobacco, tobacco smoking; Toxicology; Weight Gain; United States; North America; America; Human; Drug addiction; Amfebutamone; Statistical analysis; Psychotropic; Distributed database; Weaning; Treatment efficiency; Tobacco smoking; Statistics; Long term; Computer science; Placebo; Antidepressant agent; Clinical trial; Patch; Public health; Nicotine

Each year, approximately 20 million of the 50 million smokers in the United States try to quit smoking, but only about 6 percent of those who try succeed in quitting in the long term. 1 Nicotine-replacement therapies, such as the nicotine patch and nicotine gum, boost the rates of smoking cessation...