A Controlled Trial of Sustained-Release Bupropion, a Nicotine Patch, or Both for Smoking Cessation

Each year, approximately 20 million of the 50 million smokers in the United States try to quit smoking, but only about 6 percent of those who try succeed in quitting in the long term. 1 Nicotine-replacement therapies, such as the nicotine patch and nicotine gum, boost the rates of smoking cessation...

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Bibliographic Details
Published inThe New England journal of medicine Vol. 340; no. 9; pp. 685 - 691
Main Authors Jorenby, Douglas E, Leischow, Scott J, Nides, Mitchell A, Rennard, Stephen I, Johnston, J. Andrew, Hughes, Arlene R, Smith, Stevens S, Muramoto, Myra L, Daughton, David M, Doan, Kimberli, Fiore, Michael C, Baker, Timothy B
Format Journal Article
LanguageEnglish
Published Boston, MA Massachusetts Medical Society 04.03.1999
Subjects
Administration, Cutaneous
Adult
Antidepressive Agents, Second-Generation - adverse effects
Antidepressive Agents, Second-Generation - therapeutic use
Biological and medical sciences
Bupropion - adverse effects
Bupropion - therapeutic use
Delayed-Action Preparations
Drug therapy
Drug Therapy, Combination
Female
Humans
Male
Medical research
Medical sciences
Nicotine - adverse effects
Nicotine - therapeutic use
Smoking cessation
Smoking Cessation - methods
Smoking Cessation - psychology
Smoking Cessation - statistics & numerical data
Substance Withdrawal Syndrome
Tobacco, tobacco smoking
Toxicology
Weight Gain
United States
North America
America
Human
Drug addiction
Amfebutamone
Statistical analysis
Psychotropic
Distributed database
Weaning
Treatment efficiency
Tobacco smoking
Statistics
Long term
Computer science
Placebo
Antidepressant agent
Clinical trial
Patch
Public health
Nicotine
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Summary:Each year, approximately 20 million of the 50 million smokers in the United States try to quit smoking, but only about 6 percent of those who try succeed in quitting in the long term. 1 Nicotine-replacement therapies, such as the nicotine patch and nicotine gum, boost the rates of smoking cessation by a factor of 1.4 to 2.6 in comparison with placebo treatments, 2 but 70 to 80 percent of smokers who use these therapies still start to smoke again. Affect or mood appears to exert potent effects on the motivation to use nicotine. 3 – 5 For instance, among smokers, symptoms of nicotine . . .
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ISSN:0028-4793
1533-4406
DOI:10.1056/NEJM199903043400903