A missing dimension in measures of vaccination impacts

  Any infectious processes must depend in some fashion on dose, and empirical evidence exists for an effect of exposure dose on the probability of transmission to mumps-vaccinated hosts [1], the case-fatality ratio of measles [2], and the probability of infection and, given infection, of symptoms in...

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Published inPLoS pathogens Vol. 10; no. 3; p. e1003849
Main Authors Gomes, M Gabriela M, Lipsitch, Marc, Wargo, Andrew R, Kurath, Gael, Rebelo, Carlota, Medley, Graham F, Coutinho, Antonio
Format Journal Article
LanguageEnglish
Published United States Public Library of Science 01.03.2014
Public Library of Science (PLoS)
Subjects
Animals
Experiments
Host-parasite relationships
Humans
Immunological research
Infections
Intervention
Medicine
Models, Biological
Opinion
Population
Vaccination
Vaccines
United Kingdom
Animals
Vaccines
Models, Biological
Humans
Vaccination
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Summary:  Any infectious processes must depend in some fashion on dose, and empirical evidence exists for an effect of exposure dose on the probability of transmission to mumps-vaccinated hosts [1], the case-fatality ratio of measles [2], and the probability of infection and, given infection, of symptoms in cholera [3]. Simulated sets of dose-infectivity data were generated and used to estimate model parameters (Figure S2), assuming the host susceptibility of the intervention group described by a beta distribution, , with shape parameters positioned as a grid in a square neighborhood of the uniform distribution, .
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The authors have declared that no competing interests exist.
ISSN:1553-7374
1553-7366
1553-7374
DOI:10.1371/journal.ppat.1003849