Effects of orally administered bovine lactoperoxidase on dextran sulfate sodium-induced colitis in mice

• Published in: Bioscience, biotechnology, and biochemistry Vol. 72; no. 7; pp. 1932 - 1935
• Main Authors: Shin, K.(Morinaga Milk Industry Co. Ltd., Zama, Kanagawa (Japan)), Horigome, A, Yamauchi, K, Takase, M, Yaeshima, T, Iwatsuki, K
• Format: Journal Article
• Language: English
• Published: Tokyo Japan Society for Bioscience, Biotechnology, and Agrochemistry 01.07.2008; Japan Society for Bioscience Biotechnology and Agrochemistry; Oxford University Press
• Subjects: ADMINISTRACION ORAL; ADMINISTRATION ORALE; Administration, Oral; ALBUMINAS; ALBUMINE; ALBUMINS; Animals; Anti-Inflammatory Agents; Biological and medical sciences; Cattle; COLITE; COLITIS; Colitis - chemically induced; Colitis - drug therapy; Colitis - pathology; Dextran Sulfate; dextran sulphate sodium; Fundamental and applied biological sciences. Psychology; interleukin-6; INTERLEUKINE; INTERLEUKINS; INTERLEUQUINAS; INTESTIN; INTESTINES; INTESTINOS; LACTOPEROXIDASA; LACTOPEROXIDASE; Lactoperoxidase - administration & dosage; Lactoperoxidase - pharmacology; Lactoperoxidase - therapeutic use; LACTOPEROXYDASE; MICE; ORAL ADMINISTRATION; RATON; SOURIS; Treatment Outcome; Bovine; Cytokine; Rodentia; Sulfates; interleukin-6; Dextran; Interleukin 6; Vertebrata; Mammalia; Sodium; Mouse; dextran sulphate sodium; Artiodactyla; Colitis; Ungulata; lactoperoxidase
• ISSN: 0916-8451; 1347-6947
• DOI: 10.1271/bbb.70636

The effect of lactoperoxidase (LPO) on dextran sulfate sodium-induced colitis was examined in mice. After 9 d of colitis induction, weight loss, colon shortening and the histological score were significantly suppressed in mice orally administered LPO (62.5 mg/body/d) as compared to a group administered bovine serum albumin. These results suggest that LPO exhibits anti-inflammatory effects in the gastrointestinal tract.