Presence of highly oncogenic human papillomavirus in the oral mucosa of asymptomatic men

• Published in: The Brazilian journal of infectious diseases Vol. 18; no. 3; pp. 266 - 270
• Main Authors: Machado, Ana Paula, Gatto de Almeida, Flávia, Bonin, Camila Mareti, Martins Prata, Thiago Theodoro, Sobrinho Ávilla, Leandro, Junqueira Padovani, Cacilda Tezelli, Teixeira Ferreira, Alda Maria, dos Santos Fernandes, Carlos Eurico, Tozetti, Inês Aparecida
• Format: Journal Article
• Language: English
• Published: Brazil Elsevier Editora Ltda 01.05.2014; Contexto; Elsevier; Brazilian Society of Infectious Diseases
• Subjects: Adult; Asymptomatic Infections; Carrier state (Communicable diseases); DNA, Viral - analysis; Genotype; Human papilomavírus; Humans; Identification and classification; INFECTIOUS DISEASES; Male; Medical examination; Men; Mouth Mucosa - virology; Oral mucosa; Oral mucosal; Original; Papillomaviridae - genetics; Papillomaviridae - isolation & purification; Papillomavirus Infections - diagnosis; Papillomaviruses; Physiological aspects; Polymerase Chain Reaction; Polymorphism, Restriction Fragment Length; Viral type; Human papilomavírus; Viral type; Men; Oral mucosal
• ISSN: 1413-8670; 1678-4391; 1678-4391
• DOI: 10.1016/j.bjid.2013.07.013

The aim of this study was to identify highly oncogenic forms of human papillomavirus in the oral mucosa of asymptomatic men. In this study, we analyzed samples of exfoliated cells from the oral cavity of 559 asymptomatic men. DNA-human papillomavirus was detected using the consensus primers PGMY09/11; viral genotyping was performed using type-specific PCR and restriction fragment length polymorphism. DNA-human papillomavirus was detected in 1.3% of the study participants and of those 42.8% were infected by more than one type of virus. Viral types included HPV6, 11, 89 (low oncogenic risk), and HPV52, 53 (high oncogenic risk). Increased vulnerability to human papillomavirus infection was observed in individuals aged over 26 years, among those who reported oral sex practices, and in those who have had more than 16 sexual partners since first engaging in sexual intercourse. There was a low prevalence of human papillomavirus detection in the oral mucosa of asymptomatic men. Highly oncogenic human papillomavirus types and infection by more than one viral type was observed. Oral sex practices and a large number of sexual partners may increase the risk of acquiring human papillomavirus infection.