Peripheral monocyte count: an independent diagnostic and prognostic biomarker for prostate cancer - a large Chinese cohort study

• Published in: Asian journal of andrology Vol. 19; no. 5; pp. 579 - 585
• Main Authors: Wang, Yan-Qing, Zhu, Yin-Jie, Pan, Jia-Hua, Xu, Fan, Shao, Xiao-Guang, Sha, Jian-Jun, Liu, Qiang, Huang, Yi-Ran, Dong, Bai-Jun, Xue, Wei
• Format: Journal Article
• Language: English
• Published: China Medknow Publications and Media Pvt. Ltd 01.09.2017; Medknow Publications & Media Pvt. Ltd; Medknow Publications & Media Pvt Ltd; Wolters Kluwer Medknow Publications
• Subjects: Age Factors; Aged; Androgens; Antigens; Asian Continental Ancestry Group; Biomarkers, Tumor; Biopsy; Blood; Cancer diagnosis; Cancer therapies; Case studies; Cohort analysis; Cohort Studies; Diagnosis; diagnosis; monocyte; prognosis; prostate cancer; Disease-Free Survival; Endoscopic Ultrasound-Guided Fine Needle Aspiration; Gene expression; Humans; Laboratories; Leukocyte Count; Liver cancer; Lymphoma; Male; Medical prognosis; Metastasis; Monocytes; Neutrophils; Original; Predictive Value of Tests; Prognosis; Prostate cancer; Prostate-Specific Antigen - blood; Prostatic Neoplasms - blood; Prostatic Neoplasms - diagnosis; Regression analysis; Retrospective Studies; Statistical analysis; Survival Analysis; Variables; China; United States > US
• ISSN: 1008-682X; 1745-7262
• DOI: 10.4103/1008-682X.186185

Increasing evidence indicates that inflammation may play important roles in tumorigenesis and progression, and an elevated peripheral monocyte count predicts a poor prognosis in various types of malignancies. Here, we evaluate the roles of peripheral monocyte count in the diagnosis and prognosis for prostate cancer in Chinese patients. A total of 1107 consecutive patients who had undergone prostate biopsy and 290 prostate cancer patients receiving androgen deprivation therapy as first-line therapy were retrospectively analyzed. The parameters were measured at the time of diagnosis. Univariate and multivariate logistic regression analyses were performed to identify the independent predictors of a positive biopsy. Patients were categorized in two groups using a cutoff point of 0.425 × 109 l-1 as calculated by the receiver-operating curve analysis for prognosis. Univariate and multivariate Cox regression analyses were performed to determine the associations of monocyte count with progression-free survival, cancer-specific survival, and overall survival. Multivariate logistic regression analyses showed that monocyte count, age, prostate-specific antigen (PSA), free/total PSA, and prostate volume were independent predictors for prostate cancer. Multivariate Cox regression analyses identified an elevated monocyte count as an independent prognostic factor for worse cancer-specific survival (hazard ratio = 2.244, P < 0.05) and overall survival (hazard ratio = 1.995, P < 0.05), but not progression-free survival (P = 0.117). Our results indicated that an elevated monocyte count was an independent diagnostic biomarker for prostate cancer, and pretreatment peripheral monocyte count might play a significant role in the prognosis of prostate cancer patients treated with androgen deprivation therapy.