Whole Blood and Red Blood Cell Manganese Reflected Signal Intensities of T1-Weighted Magnetic Resonance Images better than Plasma Manganese in Liver Cirrhotics

• Published in: Journal of Occupational Health Vol. 47; no. 1; pp. 68 - 73
• Main Authors: Choi, Younghee, Park, Ji Kang, Park, Neung Hwa, Shin, Jung Woo, Yoo, Cheol‐In, Lee, Choong Ryeol, Lee, Hun, Kim, Hyo Kyung, Kim, Sung‐Ryul, Jung, Tae‐hum, Park, Jungsun, Yoon, Chung Sik, Kim, Yangho
• Format: Journal Article
• Language: Japanese; English
• Published: Australia JAPAN SOCIETY FOR OCCUPATIONAL HEALTH 2005; John Wiley & Sons, Inc
• Subjects: Adult; Blood; Case-Control Studies; Erythrocytes; Erythrocytes - chemistry; Humans; Liver; Liver cirrhosis; Liver Cirrhosis - blood; Magnetic resonance; Magnetic Resonance Imaging - methods; Male; Manganese; Manganese - blood; Middle Aged; Occupational health; Pallidal index; Signal intensity
• ISSN: 1341-9145; 1348-9585; 1348-9585
• DOI: 10.1539/joh.47.68

Whole Blood and Red Blood Cell Manganese Reflected Signal Intensities of Ti-Weighted Magnetic Resonance Images better than Plasma Manganese in Liver Cirrhotics: Younghee CHOI, et al. Department of Occupational and Environmental Medicine, Ulsan University Hospital, South Korea-We examined whole blood (MnB), red blood cell (MnRBC), plasma (MnP) and urinary Mn (MnU) concentrations in 22 liver cirrhotics and 10 healthy controls to evaluate Mn concentration in which a fraction of biological samples best reflects pallidal signal intensities (pallidal index; Pl) on T1-weighted magnetic resonance images (MRI) in liver cirrhotics. Increased signal intensity in the globus pallidus was observed in 18 (81.8%) of the 22 patients with liver cirrhosis. In a transplanted patient, increased pallidal signals also resolved as his liver function tests normalized after liver transplantation. There were significant correlations between MnB/MnRBC and P1 (p=O.529, p=O.573, respectively) in liver cirrhotics, although no significant correlation was observed between MnP/MnU and Pl. According to a multiple linear regression, MnB and MnRBC reflected the signal intensities of T1-weighted MRI better than MnP or MnU.