MicroRNA-139 inhibits hepatocellular carcinoma cell growth through down-regulating karyopherin alpha 2

• Published in: Journal of experimental & clinical cancer research Vol. 38; no. 1; pp. 182 - 15
• Main Authors: Zan, Ying, Wang, Baofeng, Liang, Liang, Deng, Yujiao, Tian, Tian, Dai, Zhijun, Dong, Lei
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 02.05.2019; BioMed Central; BMC
• Subjects: Analysis; Apoptosis; Binding sites; Biomarkers; Breast cancer; Cancer; Cancer therapies; Carcinoma; Care and treatment; Cell cycle; Cell growth; Cells (Biology); Colony formation; Colorectal cancer; Development and progression; Epithelial-to-mesenchymal transition; Gastric cancer; Gene expression; Genetic aspects; Growth; Hepatocellular carcinoma; Kinases; Liver cancer; Medical prognosis; Metastasis; MicroRNA; MicroRNAs; Migration and invasion; Molecular biology; Patients; Phenotypes; Physiological aspects; Proteins; Roles; Statistics; Stem cells; Studies; Surgery; Survival; China; United States > US; Migration and invasion; Colony formation; Survival; Epithelial-to-mesenchymal transition

MicroRNA-139-5p (miR-139) has been shown to play important roles in hepatocellular carcinoma (HCC) development. However, the exact mechanism of miR-139 in HCC remains largely unknown. We investigated the function in human cell lines and patient tissue samples by experimental techniques in molecular...