Significant thrombocytopenia with sodium valproate in an adult patient with alcohol dependence

Sir, Valproic acid (VPA), sodium valproate, and divalproex sodium forms are antiepileptic drugs, also used as prophylactic agents for migraine headaches and as mood stabilizers in patients with bipolar disorders. [5] found that low platelet levels were typically noted in patients with serum valproat...

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Bibliographic Details
Published inIndian journal of psychiatry Vol. 60; no. 2; pp. 252 - 253
Main Authors Goyal, Sandeep, Badyal, Dinesh
Format Journal Article
LanguageEnglish
Published India Wolters Kluwer India Pvt. Ltd 01.04.2018
Medknow Publications and Media Pvt. Ltd
Medknow Publications & Media Pvt. Ltd
Medknow Publications & Media Pvt Ltd
Subjects
Alcoholism
Blood platelets
Drug dependence
Letters to Editor
Patients
Sodium
Sodium valproate
Thrombocytopenia
Valproic acid
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Summary:Sir, Valproic acid (VPA), sodium valproate, and divalproex sodium forms are antiepileptic drugs, also used as prophylactic agents for migraine headaches and as mood stabilizers in patients with bipolar disorders. [5] found that low platelet levels were typically noted in patients with serum valproate levels of over 140 μg/mL, and reduction of the medication dose usually resulted in a prompt increase in the number of platelets. Apart from acquired immune deficiency syndrome, probably alcoholism is the leading cause of thrombocytopenia. [...]alcohol-related thrombocytopenia is generally transient and platelet counts usually return to normal within one week of abstinence.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:0019-5545
1998-3794
DOI:10.4103/psychiatry.IndianJPsychiatry_158_17