The adaptive evolution of virulence: a review of theoretical predictions and empirical tests

• Published in: Parasitology Vol. 143; no. 7; pp. 915 - 930
• Main Authors: CRESSLER, CLAYTON E., McLEOD, DAVID V., ROZINS, CARLY, VAN DEN HOOGEN, JOSÉE, DAY, TROY
• Format: Journal Article
• Language: English
• Published: Cambridge, UK Cambridge University Press 01.06.2016; Cambridge University Press (CUP)
• Subjects: Animals; Biological Evolution; evolutionary adaptation; Host-Parasite Interactions; Humans; Models, Biological; Parasites; Parasites - pathogenicity; prediction; Special Issue Review; Virulence; Tradeoff hypothesis; infectious disease; evolutionary medicine
• ISSN: 0031-1820; 1469-8161; 1469-8161
• DOI: 10.1017/s003118201500092x

Why is it that some parasites cause high levels of host damage (i.e. virulence) whereas others are relatively benign? There are now numerous reviews of virulence evolution in the literature but it is nevertheless still difficult to find a comprehensive treatment of the theory and data on the subject that is easily accessible to non-specialists. Here we attempt to do so by distilling the vast theoretical literature on the topic into a set of relatively few robust predictions. We then provide a comprehensive assessment of the available empirical literature that tests these predictions. Our results show that there have been some notable successes in integrating theory and data but also that theory and empiricism in this field do not ‘speak’ to each other very well. We offer a few suggestions for how the connection between the two might be improved.