Effectiveness of Whole, Inactivated, Low Pathogenicity Influenza A(H7N9) Vaccine against Antigenically Distinct, Highly Pathogenic H7N9 Virus
The recent emergence of highly pathogenic influenza A(H7N9) variants poses a great risk to humans. We show that ferrets vaccinated with low pathogenicity H7N9 virus vaccine do not develop severe symptoms after infection with an antigenically distinct, highly pathogenic H7N9 virus. These results demo...
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| Published in | Emerging Infectious Diseases Vol. 24; no. 10; pp. 1910 - 1913 |
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| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Centers for Disease Control and Prevention (CDC)
01.10.2018
U.S. National Center for Infectious Diseases Centers for Disease Control and Prevention |
| Subjects | |
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| Abstract | The recent emergence of highly pathogenic influenza A(H7N9) variants poses a great risk to humans. We show that ferrets vaccinated with low pathogenicity H7N9 virus vaccine do not develop severe symptoms after infection with an antigenically distinct, highly pathogenic H7N9 virus. These results demonstrate the protective benefits of this H7N9 vaccine. |
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| AbstractList | The recent emergence of highly pathogenic influenza A(H7N9) variants poses a great risk to humans. We show that ferrets vaccinated with low pathogenicity H7N9 virus vaccine do not develop severe symptoms after infection with an antigenically distinct, highly pathogenic H7N9 virus. These results demonstrate the protective benefits of this H7N9 vaccine.The recent emergence of highly pathogenic influenza A(H7N9) variants poses a great risk to humans. We show that ferrets vaccinated with low pathogenicity H7N9 virus vaccine do not develop severe symptoms after infection with an antigenically distinct, highly pathogenic H7N9 virus. These results demonstrate the protective benefits of this H7N9 vaccine. The recent emergence of highly pathogenic influenza A(H7N9) variants poses a great risk to humans. We show that ferrets vaccinated with low pathogenicity H7N9 virus vaccine do not develop severe symptoms after infection with an antigenically distinct, highly pathogenic H7N9 virus. These results demonstrate the protective benefits of this H7N9 vaccine. |
| Audience | Professional Academic |
| Author | Gongxun Zhong Masato Hatta Tiago J. S. Lopes Shiho Chiba Yoshihiro Kawaoka Gabriele Neumann |
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| Cites_doi | 10.1016/j.chom.2017.09.008 10.5582/bst.2017.01040 10.1016/S1473-3099(17)30323-7 10.5365/wpsar.2017.8.1.001 10.15585/mmwr.mm6609e2 10.1038/ncomms9148 10.1385/1-59259-083-7:211 |
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| Keywords | highly pathogenic influenza vaccine viruses H7N9 low pathogenicity |
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| References | Iuliano (key-10.3201/eid2410.180403-201809130829-R5) 2017; 66 key-10.3201/eid2410.180403-201809130829-R1 Wang (key-10.3201/eid2410.180403-201809130829-R3) 2017; 17 Imai (key-10.3201/eid2410.180403-201809130829-R10) 2017; 22 key-10.3201/eid2410.180403-201809130829-R12 key-10.3201/eid2410.180403-201809130829-R7 key-10.3201/eid2410.180403-201809130829-R6 Shen (key-10.3201/eid2410.180403-201809130829-R2) 2017; 11 (key-10.3201/eid2410.180403-201809130829-R11) 2017; 92 Zhou (key-10.3201/eid2410.180403-201809130829-R4) 2017; 8 Ping (key-10.3201/eid2410.180403-201809130829-R8) 2015; 6 key-10.3201/eid2410.180403-201809130829-R9 |
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| SubjectTerms | Animals Antigens, Viral Antigens, Viral - immunology Development and progression Disease Models, Animal Dispatch Female Ferrets H7N9 Health aspects highly pathogenic Humans Immunization Infectious and parasitic diseases Influenza Influenza A Virus, H7N9 Subtype Influenza A Virus, H7N9 Subtype - genetics Influenza A Virus, H7N9 Subtype - immunology Influenza A Virus, H7N9 Subtype - pathogenicity Influenza Vaccines Influenza Vaccines - genetics Influenza Vaccines - immunology Influenza, Human Influenza, Human - immunology Influenza, Human - prevention & control Influenza, Human - virology Lectins low pathogenicity Medicine Orthomyxoviridae Infections Orthomyxoviridae Infections - immunology Orthomyxoviridae Infections - prevention & control Orthomyxoviridae Infections - virology Public health R RC109-216 Recombination, Genetic Vaccination vaccine Vaccines, Inactivated Vaccines, Inactivated - genetics Vaccines, Inactivated - immunology Virulence viruses |
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| Title | Effectiveness of Whole, Inactivated, Low Pathogenicity Influenza A(H7N9) Vaccine against Antigenically Distinct, Highly Pathogenic H7N9 Virus |
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