Effectiveness of Whole, Inactivated, Low Pathogenicity Influenza A(H7N9) Vaccine against Antigenically Distinct, Highly Pathogenic H7N9 Virus

The recent emergence of highly pathogenic influenza A(H7N9) variants poses a great risk to humans. We show that ferrets vaccinated with low pathogenicity H7N9 virus vaccine do not develop severe symptoms after infection with an antigenically distinct, highly pathogenic H7N9 virus. These results demo...

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Bibliographic Details
Published inEmerging Infectious Diseases Vol. 24; no. 10; pp. 1910 - 1913
Main Authors Hatta, Masato, Zhong, Gongxun, Chiba, Shiho, Lopes, Tiago J.S., Neumann, Gabriele, Kawaoka, Yoshihiro
Format Journal Article
LanguageEnglish
Published United States Centers for Disease Control and Prevention (CDC) 01.10.2018
U.S. National Center for Infectious Diseases
Centers for Disease Control and Prevention
Subjects
Animals
Antigens, Viral
Antigens, Viral - immunology
Development and progression
Disease Models, Animal
Dispatch
Female
Ferrets
H7N9
Health aspects
highly pathogenic
Humans
Immunization
Infectious and parasitic diseases
Influenza
Influenza A Virus, H7N9 Subtype
Influenza A Virus, H7N9 Subtype - genetics
Influenza A Virus, H7N9 Subtype - immunology
Influenza A Virus, H7N9 Subtype - pathogenicity
Influenza Vaccines
Influenza Vaccines - genetics
Influenza Vaccines - immunology
Influenza, Human
Influenza, Human - immunology
Influenza, Human - prevention & control
Influenza, Human - virology
Lectins
low pathogenicity
Medicine
Orthomyxoviridae Infections
Orthomyxoviridae Infections - immunology
Orthomyxoviridae Infections - prevention & control
Orthomyxoviridae Infections - virology
Public health
R
RC109-216
Recombination, Genetic
Vaccination
vaccine
Vaccines, Inactivated
Vaccines, Inactivated - genetics
Vaccines, Inactivated - immunology
Virulence
viruses
highly pathogenic
influenza
vaccine
viruses
H7N9
low pathogenicity
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Summary:The recent emergence of highly pathogenic influenza A(H7N9) variants poses a great risk to humans. We show that ferrets vaccinated with low pathogenicity H7N9 virus vaccine do not develop severe symptoms after infection with an antigenically distinct, highly pathogenic H7N9 virus. These results demonstrate the protective benefits of this H7N9 vaccine.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1080-6040
1080-6059
1080-6059
DOI:10.3201/eid2410.180403