Recent progress in biocatalysis using supercritical carbon dioxide

• Published in: Journal of bioscience and bioengineering Vol. 115; no. 3; pp. 233 - 241
• Main Author: Matsuda, Tomoko
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 01.03.2013; Elsevier
• Subjects: Alcohol dehydrogenase; Alcohol Dehydrogenase - metabolism; Asymmetric synthesis; Biocatalysis; Bioconversions. Hemisynthesis; Biological and medical sciences; Biotechnology; Candida antarctica lipase B; Carbon dioxide; Carbon Dioxide - chemistry; carboxylation; Chemistry Techniques, Synthetic; decarboxylases; Enzyme; Enzyme Stability; Fundamental and applied biological sciences. Psychology; Geotrichum candidum; Lipase - metabolism; lipases; Methods. Procedures. Technologies; Novozym 435; Organic synthesis; Solvents - chemistry; Supercritical fluid; Organic synthesis; Biocatalysis; Geotrichum candidum; Asymmetric synthesis; Enzyme; Carbon dioxide; Candida antarctica lipase B; Supercritical fluid; Alcohol dehydrogenase; Novozym 435; candida antarctica; Triacylglycerol lipase; Esterases; Supercritical state; Carboxylic ester hydrolases; Fungi; Hydrolases; Fungi Imperfecti; Oxidoreductases
• ISSN: 1389-1723; 1347-4421; 1347-4421
• DOI: 10.1016/j.jbiosc.2012.10.002

The latest advances in biocatalysis using supercritical carbon dioxide (scCO2) are reviewed. Stability and stabilization methodologies of enzymes in scCO2 as well as reactions for organic synthesis are described. Especially, varieties of examples for lipase-catalyzed synthesis of chiral compounds using scCO2 are given. Furthermore, asymmetric reduction by alcohol dehydrogenase in scCO2 and carboxylation by decarboxylase in scCO2 are also introduced.