The paradigm of protein acetylation in Parkinson's disease

• Published in: Neural regeneration research Vol. 14; no. 6; pp. 975 - 976
• Main Authors: Yakhine-Diop, Sokhna, Martínez-Chacón, Guadalupe, Uribe-Carretero, Elisabet, Niso-Santano, Mireia, González-Polo, Rosa, Fuentes, José
• Format: Journal Article
• Language: English
• Published: India Wolters Kluwer India Pvt. Ltd 01.06.2019; Medknow Publications and Media Pvt. Ltd; Medknow Publications & Media Pvt. Ltd; Instituto de Investigación Biosanitaria de Extremadura (INUBE), Spain; Centro de Investigación Biomédica en Red en Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain; Universidad de Extremadura,Departamento de Bioquímicay Biología Moleculary Genética,Facultad de Enfermeríay Terapia Ocupacional, Cáceres, Spain; Medknow Publications & Media Pvt Ltd; Wolters Kluwer Medknow Publications
• Subjects: Acetates; Acetylation; Acids; Apoptosis; Autophagy; Biochemistry; Cell death; Enzymes; Fibroblasts; Gene expression; Genes; Genetic aspects; Hats; Kinases; Lysine; Mitochondria; Neuroblastoma; Parkinson disease; Parkinson's disease; Peptides; Polo; Post-translational modifications; Proteins; Spain
• ISSN: 1673-5374; 1876-7958
• DOI: 10.4103/1673-5374.250575

[...]in vivo, paraquat-induced upregulation of α-synuclein triggers histone hypoacetylation. [...]in PD models, proteins are hypoacetylated or hyperacetylated in response to a stimulus. Though the unspecific inhibitor of class I and II HDACs, TSA, reestablished the reduced histone 3 acetylation level at lysine 17, its effect was harmful (Yakhine-Diop et al., 2018a). [...]a specific inhibition of class I and II HADCs could be protective as previously reported (Collins et al., 2015; Choong et al., 2016). The diminution of HDAC6 increases the level of acetylated tubulin at lysine 40 [Figure 1]. [...]the only difference in class I HDAC expression occurring between IPD and GPD was HDAC3 protein [Figure 1] and might be involved in the hypoacetylation of nuclear proteins (histone 3 and 4).