Opioid-Induced Central Immune Signaling: Implications for Opioid Analgesia

Despite being the mainstay of pain management, opioids are limited in their clinical utility by adverse effects, such as tolerance and paradoxical hyperalgesia. Research of the past 15 years has extended beyond neurons, to implicate central nervous system immune signaling in these adverse effects. T...

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Published inHeadache Vol. 55; no. 4; pp. 475 - 489
Main Authors Grace, Peter M., Maier, Steven F., Watkins, Linda R.
Format Journal Article
LanguageEnglish
Published United States Blackwell Publishing Ltd 01.04.2015
Wiley Subscription Services, Inc
Subjects
allodynia
Analgesia - adverse effects
Analgesics, Opioid - adverse effects
Analgesics, Opioid - pharmacology
Animals
Central Nervous System - drug effects
Central Nervous System - immunology
Drug Tolerance - immunology
Humans
hyperalgesia
Hyperalgesia - chemically induced
Hyperalgesia - immunology
Medical research
Narcotics
opioid receptor
P2X4 receptor
P2X7 receptor
Pain management
Signal Transduction - drug effects
Signal Transduction - immunology
TLR4
Toll-Like Receptor 4 - immunology
opioid receptor
allodynia
hyperalgesia
P2X7 receptor
TLR4
P2X4 receptor
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Abstract Despite being the mainstay of pain management, opioids are limited in their clinical utility by adverse effects, such as tolerance and paradoxical hyperalgesia. Research of the past 15 years has extended beyond neurons, to implicate central nervous system immune signaling in these adverse effects. This article will provide an overview of these central immune mechanisms in opioid tolerance and paradoxical hyperalgesia, including those mediated by Toll‐like receptor 4, purinergic, ceramide, and chemokine signaling. Challenges for the future, as well as new lines of investigation will be highlighted.
AbstractList Despite being the mainstay of pain management, opioids are limited in their clinical utility by adverse effects, such as tolerance and paradoxical hyperalgesia. Research of the past 15 years has extended beyond neurons, to implicate central nervous system immune signaling in these adverse effects. This article will provide an overview of these central immune mechanisms in opioid tolerance and paradoxical hyperalgesia, including those mediated by Toll-like receptor 4, purinergic, ceramide, and chemokine signaling. Challenges for the future, as well as new lines of investigation will be highlighted.
Author Grace, Peter M.
Watkins, Linda R.
Maier, Steven F.
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  fullname: Maier, Steven F.
  organization: University of Colorado Boulder, CO, Boulder, USA
– sequence: 3
  givenname: Linda R.
  surname: Watkins
  fullname: Watkins, Linda R.
  organization: University of Colorado Boulder, CO, Boulder, USA
BackLink https://www.ncbi.nlm.nih.gov/pubmed/25833219$$D View this record in MEDLINE/PubMed
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Keywords opioid receptor
allodynia
hyperalgesia
P2X7 receptor
TLR4
P2X4 receptor
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  article-title: Immunosuppression by delta‐opioid antagonist naltrindole: Delta‐ and triple mu/delta/kappa‐opioid receptor knockout mice reveal a nonopioid activity
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Snippet Despite being the mainstay of pain management, opioids are limited in their clinical utility by adverse effects, such as tolerance and paradoxical...
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SubjectTerms allodynia
Analgesia - adverse effects
Analgesics, Opioid - adverse effects
Analgesics, Opioid - pharmacology
Animals
Central Nervous System - drug effects
Central Nervous System - immunology
Drug Tolerance - immunology
Humans
hyperalgesia
Hyperalgesia - chemically induced
Hyperalgesia - immunology
Medical research
Narcotics
opioid receptor
P2X4 receptor
P2X7 receptor
Pain management
Signal Transduction - drug effects
Signal Transduction - immunology
TLR4
Toll-Like Receptor 4 - immunology
Title Opioid-Induced Central Immune Signaling: Implications for Opioid Analgesia
URI https://api.istex.fr/ark:/67375/WNG-2N94LJZT-S/fulltext.pdf
https://onlinelibrary.wiley.com/doi/abs/10.1111%2Fhead.12552
https://www.ncbi.nlm.nih.gov/pubmed/25833219
https://www.proquest.com/docview/1673701597
https://search.proquest.com/docview/1674199991
https://search.proquest.com/docview/1680462499
https://pubmed.ncbi.nlm.nih.gov/PMC4402135
Volume 55
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