Opioid-Induced Central Immune Signaling: Implications for Opioid Analgesia
Despite being the mainstay of pain management, opioids are limited in their clinical utility by adverse effects, such as tolerance and paradoxical hyperalgesia. Research of the past 15 years has extended beyond neurons, to implicate central nervous system immune signaling in these adverse effects. T...
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Published in | Headache Vol. 55; no. 4; pp. 475 - 489 |
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Main Authors | , , |
Format | Journal Article |
Language | English |
Published |
United States
Blackwell Publishing Ltd
01.04.2015
Wiley Subscription Services, Inc |
Subjects | |
Online Access | Get full text |
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Summary: | Despite being the mainstay of pain management, opioids are limited in their clinical utility by adverse effects, such as tolerance and paradoxical hyperalgesia. Research of the past 15 years has extended beyond neurons, to implicate central nervous system immune signaling in these adverse effects. This article will provide an overview of these central immune mechanisms in opioid tolerance and paradoxical hyperalgesia, including those mediated by Toll‐like receptor 4, purinergic, ceramide, and chemokine signaling. Challenges for the future, as well as new lines of investigation will be highlighted. |
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Bibliography: | American Australian Association Sir Keith Murdoch Fellowship NHMRC - No. 1054091 NIH - No. DA024044; No. DE107782; No. DA023132 istex:5C5B4A6581962FF19EFCB5E846BE77B1A51F2F10 ark:/67375/WNG-2N94LJZT-S ArticleID:HEAD12552 ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1 ObjectType-Article-1 ObjectType-Feature-2 |
ISSN: | 0017-8748 1526-4610 |
DOI: | 10.1111/head.12552 |