Hlf is a genetic modifier of epilepsy caused by voltage-gated sodium channel mutations

Highlights • Genetic deletion of Hepatic leukemia factor ( Hlf ) exacerbated epilepsy in Scn2a Q54 mice. • Pyridoxine deficiency exacerbated the epilepsy phenotype of Scn2a Q54 mice. • Genetic deletion of Hlf worsened survival in the Scn1a+/− model of Dravet syndrome. • Hlf acts as a genetic modifie...

Full description

Saved in:
Bibliographic Details
Published inEpilepsy research Vol. 119; pp. 20 - 23
Main Authors Hawkins, Nicole A, Kearney, Jennifer A
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 01.01.2016
Subjects
Animals
Basic-Leucine Zipper Transcription Factors - genetics
Basic-Leucine Zipper Transcription Factors - metabolism
Brain - physiopathology
Diet
Electroencephalography
Epilepsy
Epilepsy - genetics
Epilepsy - mortality
Epilepsy - physiopathology
Genetics
Kaplan-Meier Estimate
Mice, Inbred C57BL
Mice, Transgenic
Mouse model
Mutation
NAV1.1 Voltage-Gated Sodium Channel - genetics
NAV1.1 Voltage-Gated Sodium Channel - metabolism
Neurology
Phenotype
Pyridoxine - deficiency
Seizure
Severity of Illness Index
Voltage-gated sodium channel
Genetics
Seizure
Mouse model
Epilepsy
Voltage-gated sodium channel
Online AccessGet full text

Cover

More Information
Summary:Highlights • Genetic deletion of Hepatic leukemia factor ( Hlf ) exacerbated epilepsy in Scn2a Q54 mice. • Pyridoxine deficiency exacerbated the epilepsy phenotype of Scn2a Q54 mice. • Genetic deletion of Hlf worsened survival in the Scn1a+/− model of Dravet syndrome. • Hlf acts as a genetic modifier of epilepsy, possibly by pyridoxine pathway modulation.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0920-1211
1872-6844
DOI:10.1016/j.eplepsyres.2015.11.016