Adder and a coarse-grained approach to cell size homeostasis in bacteria

Cell size control and homeostasis is a long-standing subject in biology. Recent experimental work provides extensive evidence for a simple, quantitative size homeostasis principle coined adder (as opposed to sizer or timer). The adder principle provides unexpected insights into how bacteria maintain...

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Bibliographic Details
Published inCurrent opinion in cell biology Vol. 38; pp. 38 - 44
Main Authors Sauls, John T, Li, Dongyang, Jun, Suckjoon
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.02.2016
Subjects
Bacteria
Biological Evolution
Homeostasis
Internal Medicine
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Summary:Cell size control and homeostasis is a long-standing subject in biology. Recent experimental work provides extensive evidence for a simple, quantitative size homeostasis principle coined adder (as opposed to sizer or timer). The adder principle provides unexpected insights into how bacteria maintain their size without employing a feedback mechanism. We review the genesis of adder and recent cell size homeostasis study on evolutionarily divergent bacterial organisms and beyond. We propose new coarse-grained approaches to understand the underlying mechanisms of cell size control at the whole cell level.
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These authors contributed equally to this work.
ISSN:0955-0674
1879-0410
1879-0410
DOI:10.1016/j.ceb.2016.02.004