Cutaneous manifestations of multiple myeloma

Multiple myeloma (MM) is a proliferative disorder of plasma cells which produce abnormal immunoglobulin proteins. Skin involvement is rarely found in this disorder. They are either specific or nonspecific lesions. We report four such interesting patients who presented to us initially with common der...

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Published inIndian journal of dermatology Vol. 61; no. 6; pp. 668 - 671
Main Authors Behera, Binodini, Pattnaik, Monali, Sahu, Bharti, Mohanty, Prasenjeet, Jena, Swapna, Mohapatra, Liza
Format Journal Article
LanguageEnglish
Published India Wolters Kluwer India Pvt. Ltd 01.11.2016
Medknow Publications and Media Pvt. Ltd
Medknow Publications & Media Pvt. Ltd
Medknow Publications & Media Pvt Ltd
Wolters Kluwer Medknow Publications
Subjects
Amyloidosis
Bone marrow
Care and treatment
Case Series
Case studies
Conflicts of interest
Consent
Diagnosis
Disease
Hematology
leukocytoclastic vasculitis
Medical prognosis
Multiple myeloma
Patients
pyoderma gangrenosum
Skin
Ulcers
India
leukocytoclastic vasculitis
multiple myeloma
Amyloidosis
pyoderma gangrenosum
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Summary:Multiple myeloma (MM) is a proliferative disorder of plasma cells which produce abnormal immunoglobulin proteins. Skin involvement is rarely found in this disorder. They are either specific or nonspecific lesions. We report four such interesting patients who presented to us initially with common dermatoses such as leukocytoclastic vasculitis, pyoderma gangrenosum, and vesiculobullous disorders and were subsequently diagnosed to have MM. There were no skeletal involvements or renal function abnormality at the time of presentation. Unusual presentation, nonresponsiveness to conventional therapy, and abnormal blood parameters prompted us to suspect some underlying systemic conditions which were later confirmed to be MM after serum immunoelectrophoresis for M-band and bone marrow biopsy.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:0019-5154
1998-3611
DOI:10.4103/0019-5154.193682