Peripheral neuroblastoma in a young Labrador retriever

A 2-year-old Labrador Retriever developed atrophy of the right temporal muscle, subsequently showed generalized seizure and died 2 months after the clinical onset. Postmortem examination revealed the tumor masses in the right mandibulopharyngeal area, nasopharynx and intracranial space. Histopatholo...

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Bibliographic Details
Published inJournal of Veterinary Medical Science Vol. 65; no. 2; pp. 271 - 274
Main Authors Suzuki, M. (Miyazaki Univ. (Japan). Faculty of Agriculture), Uchida, K, Taniguchi, K, Yamaguchi, R, Tateyama, S
Format Journal Article
LanguageEnglish
Published Japan JAPANESE SOCIETY OF VETERINARY SCIENCE 01.02.2003
Japan Science and Technology Agency
Subjects
Animals
canine
DIAGNOSIS
Dog Diseases - pathology
DOGS
GANGLIA
ganglion
Male
NEOPLASMS
Neuroblastoma - pathology
Neuroblastoma - veterinary
peripheral neuroblastoma
POSTMORTEM EXAMINATION
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Summary:A 2-year-old Labrador Retriever developed atrophy of the right temporal muscle, subsequently showed generalized seizure and died 2 months after the clinical onset. Postmortem examination revealed the tumor masses in the right mandibulopharyngeal area, nasopharynx and intracranial space. Histopathologically, these tumor masses were composed of small round neoplastic cells and neuropil-like stroma separated by fibrovascular septa. In the neoplastic masses, small neoplastic cells with round to oval hyperchromatic nuclei and scanty cytoplasm predominated, and angulated neoplastic cells with larger nuclei and moderate cytoplasm were scattered. Immunohistochemically, neoplastic cells were positive for neuron specific enorase, neurofilament protein, chromogranin A, synaptophysin and tyrosine hydroxylase. Based on these findings, this case was diagnosed as peripheral neuroblastoma, presumably originated from the sympathetic ganglion, maybe right craninal cervical ganglion.
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ISSN:0916-7250
1347-7439
DOI:10.1292/jvms.65.271