Using PET/CT Bone Scan Dynamic Data to Evaluate Tibia Remodeling When a Taylor Spatial Frame Is Used: Short and Longer Term Differences

• Published in: BioMed research international Vol. 2015; no. 2015; pp. 1 - 11
• Main Authors: Weidenhielm, Lars, Zeleznik, Michael P., Noz, Marilyn E., Jonsson, Cathrine, Karlsson-Thur, Charlotte, Maguire, Gerald Q., Lundblad, Henrik, Jacobsson, Hans
• Format: Journal Article
• Language: English
• Published: Cairo, Egypt Hindawi Publishing Corporation 01.01.2015; John Wiley & Sons, Inc; Hindawi Limited
• Subjects: Adolescent; Adult; Aged; Bone Remodeling; Clinical Study; Comparative analysis; CT imaging; Female; Fluorides; Fractures; Humans; Male; Medicin och hälsovetenskap; Methods; Middle Aged; Orthopedic Procedures; Orthopedics; Patient outcomes; Patients; PET imaging; Positron-Emission Tomography; Scanners; Scintigraphy; Surgeons; Surgery; Tibia - diagnostic imaging; Tomography, X-Ray Computed; Young Adult; New York; United States > US; Sweden
• ISSN: 2314-6133; 2314-6141; 2314-6141
• DOI: 10.1155/2015/574705

Eighteen consecutive patients, treated with a Taylor Spatial Frame for complex tibia conditions, gave their informed consent to undergo Na18F− PET/CT bone scans. We present a Patlak-like analysis utilizing an approximated blood time-activity curve eliminating the need for blood aliquots. Additionally, standardized uptake values (SUV) derived from dynamic acquisitions were compared to this Patlak-like approach. Spherical volumes of interest (VOIs) were drawn to include broken bone, other (normal) bone, and muscle. The SUV m ( t ) ( m = m a x , mean) and a series of slopes were computed as ( SUV m ( t i ) - SUV m ( t j ) ) / ( t i - t j ) , for pairs of time values t i and t j . A Patlak-like analysis was performed for the same time values by computing ( ( VOI p ( t i ) / VOI e ( t i ) ) - ( VOI p ( t j ) / VOI e ( t j ) ) ) / ( t i - t j ) , where p = broken bone, other bone, and muscle and e = expected activity in a VOI. Paired comparisons between Patlak-like and SUV m slopes showed good agreement by both linear regression and correlation coefficient analysis ( r = 84 % , r s = 78 % - SUV max , r = 92 % , and r s = 91 % - SUV mean ), suggesting static scans could substitute for dynamic studies. Patlak-like slope differences of 0.1 min−1 or greater between examinations and SU V max differences of ~5 usually indicated good remodeling progress, while negative Patlak-like slope differences of −0.06 min−1 usually indicated poor remodeling progress in this cohort.