Effect of a High-sucrose Diet on Abdominal Aortic Aneurysm Development in a Hypoperfusion-induced Animal Model

Abdominal aortic aneurysm (AAA) is a vascular disease that results in rupture of the abdominal aorta. The risk factors for the development of AAA include smoking, male sex, hypertension, and age. AAA has a high mortality rate, but therapy for AAA is restricted to surgery in cases of large aneurysms....

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Bibliographic Details
Published inJournal of Oleo Science Vol. 67; no. 5; pp. 589 - 597
Main Authors Miyamoto, Chie, Kugo, Hirona, Hashimoto, Keisuke, Sawaragi, Ayaka, Zaima, Nobuhiro, Moriyama, Tatsuya
Format Journal Article
LanguageEnglish
Japanese
Published Japan Japan Oil Chemists' Society 2018
Japan Science and Technology Agency
Subjects
Abdomen
abdominal aortic aneurysm
adipocyte
Aneurysms
Aorta
Aortic aneurysms
Diet
Elastin
high sucrose
Hypertension
Liver
Macrophages
Matrix metalloproteinases
Metabolism
Risk analysis
rupture
Rupturing
Sucrose
Adipocyte
high sucrose
TG
abdominal aortic aneurysm
rupture
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Summary:Abdominal aortic aneurysm (AAA) is a vascular disease that results in rupture of the abdominal aorta. The risk factors for the development of AAA include smoking, male sex, hypertension, and age. AAA has a high mortality rate, but therapy for AAA is restricted to surgery in cases of large aneurysms. Clarifying the effect of dietary food on the development of AAA would be helpful for patients with AAAs. However, the relationship between dietary habits and the development of AAA is largely unknown. In our previous study, we demonstrated that adipocytes in vascular wall can induce the rupture of AAA. Therefore, we focused on the diet-induced abnormal triglyceride metabolism, which has the potential to drive AAA development. In this study, we have evaluated the effects of a high-sucrose diet on the development of AAA in a vascular hypoperfusion-induced animal model. A high sucrose diet induced high serum TG level and fatty liver. However, the AAA rupture risk and the AAA diameter were not significantly different between the control and high-sucrose groups. The intergroup differences in the elastin degradation score and collagen-positive area were insignificant. Moreover, matrix metalloproteinases, macrophages, and monocyte chemoattractant protein-1-positive areas did not differ significantly between groups. These results suggest that a high-sucrose diet does not affect the appearance of vascular adipocyte and AAA development under the vascular hypoperfusion condition.
ISSN:1345-8957
1347-3352
DOI:10.5650/jos.ess17264