Celecoxib in breast cancer prevention and therapy

Breast cancer has a high incidence worldwide. The results of substantial studis reveal that inflammation plays an important role in the initiation, development, and aggressiveness of many malignancies. The use of celecoxib, a novel NSAID, is repetitively associated with the reduced risk of the occur...

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Bibliographic Details
Published inCancer management and research Vol. 10; pp. 4653 - 4667
Main Authors Li, Jieqing, Hao, Qiongyu, Cao, Wei, Vadgama, Jaydutt V, Wu, Yong
Format Journal Article
LanguageEnglish
Published New Zealand Dove Medical Press Limited 01.01.2018
Taylor & Francis Ltd
Dove Medical Press
Subjects
Analysis
Angiogenesis
Angiogenesis inhibitors
Anti-inflammatory agents
Antineoplastic agents
Apoptosis
B cells
Breast cancer
Cancer prevention
Cancer therapies
Cancer treatment
Celecoxib
Cell growth
Clinical trials
COX-2
Cytokines
Disease prevention
Drug dosages
Health aspects
Inflammation
Medical prognosis
Medicine
Meta-analysis
Metastasis
Nonsteroidal anti-inflammatory agents
Prevention
Review
Systematic review
Tumor necrosis factor-TNF
Tumors
Vascular endothelial growth factor
Vitamin D
Los Angeles California
United States > US
China
breast cancer
COX-2
celecoxib
inflammation
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Summary:Breast cancer has a high incidence worldwide. The results of substantial studis reveal that inflammation plays an important role in the initiation, development, and aggressiveness of many malignancies. The use of celecoxib, a novel NSAID, is repetitively associated with the reduced risk of the occurrence and progression of a number of types of cancer, particularly breast cancer. This observation is also substantiated by various meta-analyses. Clinical trials have been implemented on integration treatment of celecoxib and shown encouraging results. Celecoxib could be treated as a potential candidate for antitumor agent. There are, nonetheless, some unaddressed questions concerning the precise mechanism underlying the anticancer effect of celecoxib as well as its activity against different types of cancer. In this review, we discuss different mechanisms of anticancer effect of celecoxib as well as preclinical/clinical results signifying this beneficial effect.
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These authors contributed equally to this work
ISSN:1179-1322
1179-1322
DOI:10.2147/cmar.s178567