Retrospective hospital-based analysis of age-related macular degeneration patterns in India: 5-year follow-up

• Published in: Indian journal of ophthalmology Vol. 63; no. 12; pp. 899 - 904
• Main Authors: Sudhalkar, Aditya, Sethi, Vaibhav, Gogte, Priyanka, Bondalapati, Sailaja, Khodani, Mitali, Chhablani, Jay
• Format: Journal Article
• Language: English
• Published: India Wolters Kluwer - Medknow Publications 01.12.2015; Medknow Publications and Media Pvt. Ltd; Medknow Publications & Media Pvt. Ltd; Medknow Publications & Media Pvt Ltd; Wolters Kluwer Medknow Publications
• Subjects: Age-related macular degeneration; Aged; Aged, 80 and over; Angiogenesis Inhibitors - therapeutic use; anti-vascular endothelial growth factor therapy; Care and treatment; Diagnosis; Female; Fluorescein Angiography; Follow-Up Studies; Geographic Atrophy - diagnosis; Geographic Atrophy - drug therapy; Geographic Atrophy - epidemiology; hospital-based analysis; Humans; India; India - epidemiology; Intravitreal Injections; Macular degeneration; Male; Medical research; Microscopy, Confocal; Ophthalmoscopy; Original; Photochemotherapy; Physiological aspects; Precision medicine; Retrospective Studies; Tertiary Care Centers - statistics & numerical data; Tomography, Optical Coherence; Vascular Endothelial Growth Factor A - antagonists & inhibitors; Visual Acuity; Wet Macular Degeneration - diagnosis; Wet Macular Degeneration - drug therapy; Wet Macular Degeneration - epidemiology; hospital-based analysis; anti-vascular endothelial growth factor therapy; Age-related macular degeneration; India
• ISSN: 0301-4738; 1998-3689; 1998-3689
• DOI: 10.4103/0301-4738.176025

Purpose: To provide a detailed analysis of age-related macular degeneration (AMD) with a 5-year follow-up at a Tertiary Eye Care Center in India. Methods: In this retrospective institutional study, 408 eyes of 204 subjects (100 males) with a diagnosis of AMD with minimum 5-year follow-up were included. Data collected included demographics, details of the ocular exam, special investigations performed, treatment offered, complications, and systemic diseases, if any. Results: The median age was 74.24 ± 8.23 years. Median follow-up was 5.77 years. The visual acuity (VA) at baseline and last visit was 0.74 ± 0.12 (Snellen's equivalent 20/100) and 0.54 ± 0.12 logarithm of the minimum angle of resolution (Snellen's equivalent 20/50; P = 0.032) in patients with choroidal neovascular membrane (CNVM). The most common complaint was decreased vision (94.5%). AMD (any stage) was found to be bilateral in 93% of patients at baseline and 197 patients (96.56%) at 5 years. Seventeen eyes had active CNVM (12 of these were occult) at presentation. At baseline, 43 eyes had a disciform scar. Three hundred twenty-one eyes had dry AMD at baseline (geographic atrophy - 12 [3.7%] eyes). Five-year conversion rate into wet AMD and geographic atrophy was 2.87% and 3.12%. Median number of anti-vascular endothelial growth factor injections administered per patient was 2.8 ± 1.2. CNVM bilaterality was low (7.5%). Conclusion: Patients with AMD in India presented later in the course of the disease. Bilateral advanced AMD and geographic atrophy were uncommon. Five-year conversion rate into wet AMD and geographic atrophy was 2.87% and 3.12%.