Evolution of animal models in cancer vaccine development

• Published in: Vaccine Vol. 33; no. 51; pp. 7401 - 7407
• Main Authors: Wei, Wei-Zen, Jones, Richard F, Juhasz, Csaba, Gibson, Heather, Veenstra, Jesse
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 16.12.2015; Elsevier Limited
• Subjects: Allergy and Immunology; Amino acids; Animal model; Animal models; Animals; Antigens; Breast cancer; Cancer imaging; Cancer vaccine; Cancer Vaccines - immunology; Cancer Vaccines - isolation & purification; Cats; Clinical outcomes; Deoxyribonucleic acid; Disease Models, Animal; DNA; DNA vaccine; Domestic animals; Domestic cat; Drug Discovery - methods; Drug Discovery - trends; Food contamination & poisoning; Genetic engineering; HER2/neu; Immunotherapy; In situ immunization; Kinases; Medical imaging; Medical research; Metabolism; Metabolites; Metastasis; Neoplasms - immunology; Neoplasms - prevention & control; Neoplasms - therapy; Proteins; Rodents; Studies; Transgenic mouse; Tumor ablation; Tumorigenesis; Tumors; Vaccines; DNA vaccine; Animal model; Cancer vaccine; Transgenic mouse; In situ immunization; HER2/neu; Domestic cat; Cancer imaging; Tumor ablation
• ISSN: 0264-410X; 1873-2518
• DOI: 10.1016/j.vaccine.2015.07.075

Highlights • Animal models testing cancer vaccines have advanced to more closely recapitulate human immunity. • Early mouse models generating spontaneous tumors are generally artificially immunogenic. • Transgenic mouse models can better mimic natural immune tolerance but still have limitations. • Domestic cats and dogs parallel human genetic diversity, cancer development and immune tolerance. • In situ immunization via non-surgical tumor ablation permits recognition of tumor antigen.