Effects of restricted feeding on blood parameters in pregnant rabbits

• Published in: Journal of toxicological sciences Vol. 34; no. 1; pp. 129 - 137
• Main Authors: Matsuoka, Tetsuya, Mizuguchi, Hiroyasu, Mizoguchi, Yasumoto, Endho, Takako, Kamata, Ryo, Fukuda, Kazuya, Ishikawa, Tsutomu, Asano, Yuzo
• Format: Journal Article
• Language: English
• Published: Japan The Japanese Society of Toxicology 01.02.2009; Japan Science and Technology Agency
• Subjects: Abortion; Abortion, Veterinary - blood; Animals; Blood Chemical Analysis - methods; Blood Chemical Analysis - statistics & numerical data; Blood coagulation; Blood Coagulation - physiology; Blood Coagulation Factors - analysis; Blood Coagulation Tests - methods; Blood Coagulation Tests - statistics & numerical data; Blood parameters; Cesarean Section - veterinary; Female; Food Deprivation; Gestational Age; Pregnancy; Pregnancy Outcome; Pregnancy, Animal - blood; Pregnant rabbits; Progesterone - blood; Progesterone concentration; Rabbits; Restricted feeding; Time Factors; Weight Gain; Weight Loss
• ISSN: 0388-1350; 1880-3989
• DOI: 10.2131/jts.34.129

The effects of restricted feeding (20 g/day from gestational day (GD) 6 to 28) on pregnancy outcome and blood parameters were examined in pregnant rabbits. As compared with the group which was allowed free access to diet throughout the gestational period (NT group), the group subjected to restricted feeding (R group) showed significantly lower values in many parameters such as total protein, albumin and triglyceride on GDs 22 and 28, reflecting low nutritive conditions. In addition, there were significant changes in blood coagulation-related parameters, suggesting an imbalance between coagulation and anti-coagulation factors. Moreover, abortions occurred in about half of the animals of the R group between GDs 23 and 27. When aborted rabbits were compared with those which could maintain pregnancy under restricted feeding, total protein, albumin, platelets and antithrombin III values and especially blood progesterone concentration were significantly lower in aborted rabbits on GD 22, prior to occurrence of abortion. These results suggested that abortions due to restricted feeding might be brought about by lower nutritive conditions, an imbalance of blood coagulation-related factors and lower blood progesterone concentrations.