Occurrence and Spontaneous Remission of Graves' Hyperthyroidism Preceded by Painless Thyroiditis

• Published in: ENDOCRINE JOURNAL Vol. 44; no. 6; pp. 881 - 885
• Main Authors: NAGAI, YUKIHIRO, TOYA, TAISYU, FUKUOKA, KEN-ICHI, TANAKA, NOBUYOSHI, YANAGI, SEKIYA, KOBAYASHI, KEN-ICHI
• Format: Journal Article
• Language: English
• Published: Japan The Japan Endocrine Society 1997
• Subjects: Autoantibodies - immunology; Female; Graves Disease - etiology; Graves Disease - physiopathology; Graves' disease; Humans; Middle Aged; Pain - physiopathology; Painless thyroiditis; Receptors, Thyrotropin - immunology; Remission, Spontaneous; Spontaneous remission; Thyroiditis - complications; Thyroiditis - physiopathology; Thyrotoxicosis; TSH receptor antibody
• ISSN: 0918-8959; 1348-4540
• DOI: 10.1507/endocrj.44.881

A 45-year-old woman was referred to our hospital because of discomfort in the cervical region. Laboratory findings revealed thyrotoxicosis with positive TSH receptor antibodies, but acute inflammatory data were absent. After three weeks the thyroid hormone levels spontaneously decreased to hypothyroid levels, and thyroidal radioactive iodine uptake (RAID) was below normal. A needle-biopsy specimen of the thyroid gland obtained two months later showed diffuse lymphocytic thyroiditis, and she was therefore diagnosed as having had painless thyroiditis. Two months after returning to euthyroidism, a second thyrotoxicosis developed. TSH receptor antibodies remained positive, but RAIU was slightly above normal, indicating Graves' hyperthyroidism. Treatment with antithyroidal drugs was commenced but was soon discontinued due to an allergic reaction. Although only β-adrenergic antagonist was administered for treating the thyrotoxicosis, thyroid function was gradually normalized in parallel with the reduction in TSH receptor antibody. In this case, painless thyroiditis would be followed by Graves' disease and subsequent spontaneous remission.