Astrocytes: a double-edged sword in neurodegenerative diseases

• Published in: Neural regeneration research Vol. 16; no. 9; pp. 1702 - 1710
• Main Authors: Ding, Zhi-Bin, Song, Li-Juan, Wang, Qing, Kumar, Gajendra, Yan, Yu-Qing, Ma, Cun-Gen
• Format: Journal Article
• Language: English
• Published: India Wolters Kluwer India Pvt. Ltd 01.09.2021; Medknow Publications and Media Pvt. Ltd; Medknow Publications & Media Pvt. Ltd; Department of Neurology, Affiliated Shanxi Bethune Hospital, Shanxi Medical University, Taiyuan, Shanxi Province, China%The Key Research Laboratory of Benefiting Qi for Acting Blood Circulation Method to Treat Multiple Sclerosis of State Administration of Traditional Chinese Medicine, Research Center of Neurobiology, Shanxi University of Chinese Medicine, Taiyuan, Shanxi Province, China%Department of Neuroscience, City University of Hong Kong, Tat Chee Avenue, Hong Kong Special Administrative Region, China%The Key Research Laboratory of Benefiting Qi for Acting Blood Circulation Method to Treat Multiple Sclerosis of State Administration of Traditional Chinese Medicine, Research Center of Neurobiology, Shanxi University of Chinese Medicine, Taiyuan, Shanxi Province, China; institute of Brain Science, Shanxi Key Laboratory of Inflammatory Neurodegenerative Diseases, Medical School of Shanxi Datong University, Datong, Shanxi Province, China; The Key Research Laboratory of Benefiting Qi for Acting Blood Circulation Method to Treat Multiple Sclerosis of State Administration of Traditional Chinese Medicine, Research Center of Neurobiology, Shanxi University of Chinese Medicine, Taiyuan, Shanxi Province, China; Wolters Kluwer - Medknow; Wolters Kluwer Medknow Publications
• Subjects: a1; a2; astrocytes; neurodegenerative diseases; neuroinflammation; neuron; neuroprotection; neurotoxicity; polarization; reactivity; Astrocytes; Degeneration; Health aspects; Nervous system; Neurodegeneration; Neurological research; Review; China; A1; A2; neurodegenerative diseases; reactivity; neurotoxicity; neuroinflammation; neuroprotection; neuron; polarization; astrocytes

Astrocytes play multifaceted and vital roles in maintaining neurophysiological function of the central nervous system by regulating homeostasis, increasing synaptic plasticity, and sustaining neuroprotective effects. Astrocytes become activated as a result of inflammatory responses during the progre...