Dual Infection with Dengue Virus Serotype 1 and 2 in a Patient in Western Mexico

On physical examination, the patient did not have severe clinical symptoms, but he presented with myalgia, exanthema, arthralgia, abdominal pain, headache, fatigue, and nausea. Interestingly, both alanine transaminase (ALT) and aspartate transaminase (AST) remained at normal levels during this simul...

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Published inJournal of global infectious diseases Vol. 9; no. 4; pp. 164 - 165
Main Authors Espinoza-Gómez, Francisco, Delgado-Enciso, Iván, Valle-Reyes, Salvador, Vásquez, Clemente, López-Lemus, Uriel A
Format Journal Article
LanguageEnglish
Published India Medknow Publications and Media Pvt. Ltd 01.10.2017
Medknow Publications & Media Pvt. Ltd
Medknow Publications & Media Pvt Ltd
Wolters Kluwer Medknow Publications
Subjects
Cytokines
Dengue fever
Enzymes
Infections
Letter to Editor
Brazil
Mexico
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Summary:On physical examination, the patient did not have severe clinical symptoms, but he presented with myalgia, exanthema, arthralgia, abdominal pain, headache, fatigue, and nausea. Interestingly, both alanine transaminase (ALT) and aspartate transaminase (AST) remained at normal levels during this simultaneous infection, despite it has observed that dengue infection is associated with accelerated progression of liver damage during the acute infection phase. [...]is the case of interleukin-2, which is associated with an increase in ALT and AST levels, and therefore its inhibition could not only participate in the downregulation of the liver enzymes but also regulate the synthesis and release of the tumor necrosis factor-α, producing a less severe clinical course in those patients.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:0974-777X
0974-8245
DOI:10.4103/jgid.jgid_42_17