High-intensity interval training induces a modest systemic inflammatory response in active, young men

• Published in: Journal of inflammation research Vol. 7; no. default; pp. 9 - 17
• Main Authors: Zwetsloot, Kevin A, John, Casey S, Lawrence, Marcus M, Battista, Rebecca A, Shanely, R Andrew
• Format: Journal Article
• Language: English
• Published: New Zealand Dove Medical Press Limited 01.01.2014; Taylor & Francis Ltd; Dove Press; Dove Medical Press
• Subjects: Biological response modifiers; Chemokines; cycle ergometer; Cytokines; Dynamometer; Exercise; exercise training; Fitness training programs; Genetic aspects; Inflammation; inflammatory cytokines; Interval training; Laboratories; Maximum oxygen consumption; Metabolism; Neuromuscular diseases; Original Research; Oxidative stress; Physical fitness; Physiological aspects; Warm up (exercise); Workloads; United States; United States > US; exercise training; inflammatory cytokines; cycle ergometer
• ISSN: 1178-7031; 1178-7031
• DOI: 10.2147/JIR.S54721

1) the extent to which an acute session of high-intensity interval training (HIIT) increases systemic inflammatory cytokines and chemokines, and 2) whether 2 weeks of HIIT training alters the inflammatory response. Eight recreationally active males (aged 22±2 years) performed 2 weeks of HIIT on a cycle ergometer (six HIIT sessions at 8-12 intervals; 60-second intervals, 75-second active rest) at a power output equivalent to 100% of their predetermined peak oxygen uptake (VO2max). Serum samples were collected during the first and sixth HIIT sessions at rest and immediately, 15, 30, and 45 minutes post-exercise. An acute session of HIIT induced significant increases in interleukin (IL)-6, IL-8, IL-10, tumor necrosis factor-α, and monocyte chemotactic protein-1 compared with rest. The concentrations of interferon-γ, granulocyte macrophage-colony-stimulating factor, and IL-1β were unaltered with an acute session of HIIT Two weeks of training did not alter the inflammatory response to an acute bout of HIIT exercise. Maximal power achieved during a VO2max test significantly increased 4.6%, despite no improvements in VO2max after 2 weeks of HIIT. These data suggest that HIIT exercise induces a small inflammatory response in young, recreationally active men; however, 2 weeks of HIIT does not alter this response.