New proteasome inhibitors in the treatment of multiple myeloma

• Published in: Hematology, Transfusion and Cell Therapy Vol. 41; no. 1; pp. 76 - 83
• Main Authors: Hungria, Vania Tietsche de Moraes, Crusoé, Edvan de Queiroz, Bittencourt, Rosane Isabel, Maiolino, Angelo, Magalhães, Roberto José Pessoa, Sobrinho, Jairo do Nascimento, Pinto, Jorge Vaz, Fortes, Ricardo Coutinho, Moreira, Eloisa de Sá, Tanaka, Paula Yurie
• Format: Journal Article
• Language: English; Portuguese
• Published: Brazil Elsevier Editora Ltda 01.01.2019; Sociedade Brasileira de Hematologia e Hemoterapia; Associação Brasileira de Hematologia, Hemoterapia e Terapia Celular (ABHH); Elsevier
• Subjects: Bortezomib; Carfilzomib; Ixazomib; MEDICINE, GENERAL & INTERNAL; Multiple myeloma; Proteasome inhibitors; Review; Carfilzomib; Bortezomib; Ixazomib; Proteasome inhibitors; Multiple myeloma
• ISSN: 2531-1379; 2531-1387; 2531-1387
• DOI: 10.1016/j.htct.2018.07.003

The treatment of patients with relapsed and/or refractory multiple myeloma has improved considerably in the last 15 years, after the introduction of proteasome inhibitors and immunomodulatory drugs. The first clinical trials with new proteasome inhibitors have produced exciting results, particularly those comparing triplet regimens with standard doublet regimens, with a gain in progression-free survival accompanied by an acceptable safety profile and either similar or better health-related quality of life. New proteasome inhibitors hold the potential to fill unmet needs in multiple myeloma management regarding improvement of clinical outcomes, including delayed progression of disease in high-risk patients. This review summarizes the main pharmacological properties and clinical outcomes of these agents, and discusses their potential to change the whole multiple myeloma therapeutic landscape.