Nanoparticle Drug Delivery System for Glioma and Its Efficacy Improvement Strategies: A Comprehensive Review

• Published in: International journal of nanomedicine Vol. 15; pp. 2563 - 2582
• Main Authors: Li, Jie, Zhao, Jiaqian, Tan, Tiantian, Liu, Mengmeng, Zeng, Zhaowu, Zeng, Yiying, Zhang, Lele, Fu, Chaomei, Chen, Dajing, Xie, Tian
• Format: Journal Article
• Language: English
• Published: New Zealand Dove Medical Press Limited 01.01.2020; Taylor & Francis Ltd; Dove; Dove Medical Press
• Subjects: Animals; Blood-Brain Barrier - pathology; brain barrier; Brain cancer; Brain Neoplasms - drug therapy; Brain research; Brain tumors; Cancer therapies; Central nervous system; Chemotherapy; deficiencies of ndds; Drug Administration Routes; Drug Delivery Systems; Drugs; efficacy improvement strategies; Glioma; Glioma - drug therapy; Gliomas; Humans; Immune system; Ligands; Medical prognosis; nanoparticle drug delivery system; Nanoparticles; Nanoparticles - chemistry; Permeability; Polymers; Radiation therapy; Review; Tumors; China; brain barrier; glioma; deficiencies of NDDS; nanoparticle drug delivery system; efficacy improvement strategies
• ISSN: 1178-2013; 1176-9114; 1178-2013
• DOI: 10.2147/IJN.S243223

Gliomas are the most common tumor of the central nervous system. However, the presence of the brain barrier blocks the effective delivery of drugs and leads to the treatment failure of various drugs. The development of a nanoparticle drug delivery system (NDDS) can solve this problem. In this review, we summarized the brain barrier (including blood-brain barrier (BBB), blood-brain tumor barriers (BBTB), brain-cerebrospinal fluid barrier (BCB), and nose-to-brain barrier), NDDS of glioma (such as passive targeting systems, active targeting systems, and environmental responsive targeting systems), and NDDS efficacy improvement strategies and deficiencies. The research prospect of drug-targeted delivery systems for glioma is also discussed.