Screening antioxidants for the protection of cochlear sensory cells

• Published in: Neural regeneration research Vol. 13; no. 1; pp. 62 - 64
• Main Authors: Hur, Dong, Kurabi, Arwa, Ryan, Allen
• Format: Journal Article
• Language: English
• Published: India Wolters Kluwer India Pvt. Ltd 01.01.2018; Medknow Publications and Media Pvt. Ltd; Medknow Publications & Media Pvt. Ltd; Department of Otorhinolaryngology, Gyeongsang National University Changwon Hospital, Changwon, South Korea%Department of Surgery / Otolaryngology, School of Medicine,University of California, San Diego, La Jolla, CA, USA%Department of Surgery / Otolaryngology, School of Medicine,University of California, San Diego, La Jolla, CA, USA; Research Service, Veterans Administration Medical Center, San Diego, CA, USA; Department of Surgery / Otolaryngology, School of Medicine,University of California, San Diego, La Jolla, CA, USA; Medknow Publications & Media Pvt Ltd; Wolters Kluwer Medknow Publications
• Subjects: Antioxidants; Antioxidants (Nutrients); Care and treatment; Cochlea; Drugs; Enzymes; Hair cells (Sensory receptors); Health aspects; Hearing loss; Noise; Oxidative stress; Tumor necrosis factor-TNF; United States > US; @@
• ISSN: 1673-5374; 1876-7958
• DOI: 10.4103/1673-5374.224371

Because antioxidants may employ one or more of these mechanisms, differences in their effectiveness may vary with the cellular processes involved. [...]in order to effectively reduce HC loss, we are likely to need single drugs or drug combinations that block multiple aspects of ROS damage. [...]the adult cochlea is fully functional and hearing can be assessed by auditory brain stem response or distortion product of acoustic emission recordings. [...]histopathological analysis allows for the identification of the exact site of cochlear damage and protection. Disadvantages of in vivo testing include potential problems with delivering effective levels of antioxidants to the cochlea. [...]testing large numbers of drugs is impractical, time consuming and costly.