Patterns of PrEP continuation and coverage in the first year of use: a latent class analysis of a programmatic PrEP trial in Kenya

• Published in: Journal of the International AIDS Society Vol. 26; no. 7; pp. e26137 - n/a
• Main Authors: Mugwanya, Kenneth K., Palayew, Adam, Schaafsma, Torin, Irungu, Elizabeth M., Bukusi, Elizabeth, Mugo, Nelly, Morton, Jennifer, Odoyo, Josephine, Ngure, Kenneth, Baeten, Jared M.
• Format: Journal Article
• Language: English
• Published: Switzerland John Wiley & Sons, Inc 01.07.2023; John Wiley and Sons Inc; Wiley
• Subjects: Acquired immune deficiency syndrome; adherence; Adult; AIDS; Analysis; Anti-HIV Agents - therapeutic use; Data collection; Disease prevention; Drugstores; Evaluation; Female; HIV; HIV infection; HIV Infections - drug therapy; HIV Infections - prevention & control; HIV prevention; Human immunodeficiency virus; Humans; Kenya; Latent Class Analysis; Male; Patient compliance; Pharmacy; Population; Pre-Exposure Prophylaxis; PrEP; Prevention; Public health; Public health administration; Reconciliation; retention; Risk assessment; risk factors; Kenya; risk factors; HIV prevention; PrEP; Kenya; adherence; retention
• ISSN: 1758-2652; 1758-2652
• DOI: 10.1002/jia2.26137

Introduction Effective PrEP use is critical for impact, but data are limited on common patterns of continuation and coverage among persons using PrEP in real‐world settings. Methods Data are from the Partners Scale‐Up Project, a programmatic stepped‐wedge cluster‐randomized trial to integrate PrEP delivery in 25 Kenyan public health facilities conducted between February 2017 and December 2021. We evaluated PrEP continuation using visit attendance and pharmacy refill records, and computed medication possession ratio to define coverage during the first year of use. Latent class mixture models were used to identify and characterize membership to different PrEP continuation patterns. Multinomial logistic regression was used to examine the association between group trajectories and demographic and behaviour characteristics. Results Overall, 4898 persons initiated PrEP, 54% (2640) were female, mean age was 33 years (standard deviation 11) and 84% (4092) had partners living with HIV. PrEP continuation was 57%, 44%, and 34% at 1, 3, and 6 months, respectively. Four unique trajectories of PrEP coverage were identified: (1) one‐fourth (1154) exhibited consistent high coverage throughout the year with 93%, 94%, 96%, and 67% continuing PrEP at months 1, 3, 6, and 12, respectively; (2) 13% (682) showed high coverage trajectory throughout 6 months but coverage rapidly declined thereafter (94%, 93%, 63%, and 10% continued at months 1, 3, 6, and 12, respectively); (3) 18.9% (918) exhibited moderate coverage trajectory with 91% of clients refilling PrEP at month 1 but nearly all dropped‐off thereafter (37%, 5%, and 4% continued at months 3, 6, and 12, respectively); and (4) 43.8% (2144) exhibited immediate discontinuation trajectory, in which nearly all did not have any subsequent PrEP refill. Overall, being female, older age, having partners living with HIV or of unknown HIV status were statistically associated with better PrEP continuation trajectories compared to the immediate discontinuation trajectory (p <0.05 for all). Conclusions In this analysis of a real‐world PrEP implementation programme in Kenya, we found four distinct patterns of PrEP continuation, with one‐third of users exhibiting consistent high continuation throughout 12 months and two‐fifths with immediate discontinuation patterns. These data may help guide tailored interventions to support PrEP continuation in this setting.