Changes in corneal higher-order aberrations during treatment for infectious keratitis

• Published in: Scientific reports Vol. 13; no. 1; p. 848
• Main Authors: Matsumura, Takehiro, Yamaguchi, Takefumi, Suzuki, Takanori, Ogiwara, Yurina, Takamura, Yoshihiro, Inatani, Masaru, Shimazaki, Jun
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 16.01.2023; Nature Publishing Group; Nature Portfolio
• Subjects: 692/699/3161; 692/699/3161/3163; Acuity; Cornea; Corneal Topography - methods; Corneal Wavefront Aberration - drug therapy; Humanities and Social Sciences; Humans; Keratitis; Keratitis - drug therapy; multidisciplinary; Retrospective Studies; Science; Science (multidisciplinary); Visual acuity
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-023-28145-7

This study aimed to quantify the changes in corneal higher-order aberrations (HOAs) before and after treatment for infectious keratitis and verify the correlation between corneal HOAs and visual acuity. Corneal HOAs were analysed using swept-source anterior segment optical coherence tomography (AS-OCT). Ninety-eight eyes of 96 consecutive patients with infectious keratitis treated with topical eye drops were retrospectively evaluated. Corneal HOAs increased with the infection but decreased with infection resolution following antimicrobial treatment. Corneal HOAs became larger as the degree of corneal findings became more severe. The increase in HOAs of the total cornea was correlated with the decrease in visual acuity both before and after treatment (4 mm, ρ = 0.530 and 0.590; 6 mm, ρ = 0.479 and 0.567, respectively; all P  < 0.0001). Furthermore, pretreatment HOA (anterior, 6 mm), pretreatment logMAR best spectacle-corrected visual acuity, and age were prognostic factors significantly associated with posttreatment visual acuity (β = 0.31, P  = 0.013; β = 0.36, P  < 0.0001; and β = 0.35, P  = 0.0007, respectively) (adjusted R 2  = 0.474). These results indicate that corneal HOAs quantified using AS-OCT can be used as an objective index to evaluate corneal optical function during the treatment of infectious keratitis.