The role of necroptosis in neurosurgical diseases

• Published in: Brazilian journal of medical and biological research Vol. 48; no. 4; pp. 292 - 298
• Main Authors: Liu, T, Bao, Y H, Wang, Y, Jiang, J Y
• Format: Journal Article
• Language: English; Portuguese
• Published: Brazil Associacao Brasileira de Divulgacao Cientifica (ABDC) 01.04.2015; Associação Brasileira de Divulgação Científica
• Subjects: Apoptosis - physiology; BIOLOGY; Brain Injuries - pathology; Brain Injuries - physiopathology; Brain Injuries - therapy; Cell Death; Cellular signal transduction; Cerebrovascular Disorders - pathology; Cerebrovascular Disorders - physiopathology; Cerebrovascular Disorders - therapy; Death Domain Receptor Signaling Adaptor Proteins - physiology; Humans; Hydroxycholesterols - pharmacology; MEDICINE, RESEARCH & EXPERIMENTAL; Molecular mechanism; Necrosis; Necrosis - physiopathology; Necrosis - therapy; Nervous system diseases; Neuroprotective Agents - antagonists & inhibitors; Pathogenesis; Programmed cell death; Receptors, Death Domain - physiology; Reviews; Signal Transduction - physiology; Therapy; Toll-Like Receptors - physiology; Therapy; Programmed cell death; Pathogenesis; Molecular mechanism
• ISSN: 0100-879X; 1414-431X; 1414-431X
• DOI: 10.1590/1414-431X20144310

Programmed necrosis or necroptosis is an alternative form of cell death that is executed through a caspase-independent pathway. Necroptosis has been implicated in many pathological conditions. Genetic or pharmacological inhibition of necroptotic signaling has been shown to confer neuroprotection after traumatic and ischemic brain injury. Therefore, the necroptotic pathway represents a potential target for neurological diseases that are managed by neurosurgeons. In this review, we summarize recent advances in the understanding of necroptotic signaling pathways and explore the role of necroptotic cell death in craniocerebral trauma, brain tumors, and cerebrovascular diseases.