Enhanced Infrared Neural Stimulation using Localized Surface Plasmon Resonance of Gold Nanorods

An advanced optical activation of neural tissues is demonstrated using pulsed infrared light and plasmonic gold nanorods. Photothermal effect localized in plasma membrane triggers action potentials of in vivo neural tissues. Compared with conventional infrared stimulation, the suggested method can i...

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Published inSmall (Weinheim an der Bergstrasse, Germany) Vol. 10; no. 19; pp. 3853 - 3857
Main Authors Eom, Kyungsik, Kim, Jinhyung, Choi, Jong Min, Kang, Taekyeong, Chang, Jin Woo, Byun, Kyung Min, Jun, Sang Beom, Kim, Sung June
Format Journal Article
LanguageEnglish
Published Germany Blackwell Publishing Ltd 01.10.2014
Wiley Subscription Services, Inc
Subjects
Action Potentials
Animals
Biomedical materials
Cell Membrane - metabolism
Gold
Gold - chemistry
gold nanoparticles
In vivo testing
In vivo tests
Infrared
infrared neural stimulation
Lasers
Male
Metal Nanoparticles - chemistry
Microscopy, Electron, Transmission
Nanorods
Nanotechnology
Nanotubes - chemistry
Neurons - metabolism
Neurons - pathology
Optics and Photonics
Photochemistry
photothermal effect
Plasmonics
Rats
Rats, Sprague-Dawley
Spectrophotometry, Infrared
Stimulation
Surface Plasmon Resonance
infrared neural stimulation
gold nanoparticles
photothermal effect
surface plasmon resonance
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Summary:An advanced optical activation of neural tissues is demonstrated using pulsed infrared light and plasmonic gold nanorods. Photothermal effect localized in plasma membrane triggers action potentials of in vivo neural tissues. Compared with conventional infrared stimulation, the suggested method can increase a neural responsivity and lower a threshold stimulation level significantly, thereby reducing a requisite radiant exposure and the concern of tissue damage.
Bibliography:ark:/67375/WNG-W955KJT8-2
istex:ED6DCA228196CFF72A856AA2179E2EFE67835422
ArticleID:SMLL201400599
Korea government (MEST) - No. 2011-0029485; No. 2011-0014529; No. 2012-0003809; No. NSF-2013R1A1A1A05011990; No. NSF-2014R1A1A1A05003770
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Ministry of Education, Science and Technology - No. NRF-2009-0082961
Technology Innovation Program - No. 10033657
Ministry of Knowledge Economy (MKE)
Global Frontier Project - No. CISS-2013072261
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ISSN:1613-6810
1613-6829
DOI:10.1002/smll.201400599