Lipase-Supported Metal-Organic Framework Bioreactor Catalyzes Warfarin Synthesis

• Published in: Chemistry : a European journal Vol. 21; no. 1; pp. 115 - 119
• Main Authors: Liu, Wan-Ling, Yang, Ni-Shin, Chen, Ya-Ting, Lirio, Stephen, Wu, Cheng-You, Lin, Chia-Her, Huang, Hsi-Ya
• Format: Journal Article
• Language: English
• Published: Weinheim WILEY-VCH Verlag 02.01.2015; WILEY‐VCH Verlag; Wiley; Wiley Subscription Services, Inc
• Subjects: Agrochemicals; Anticoagulants; Anticoagulants - chemistry; Anticoagulants - metabolism; Biocatalysis; Bioreactors; Chemistry; Chemistry, Multidisciplinary; Clinical medicine; Enzymes, Immobilized - chemistry; Enzymes, Immobilized - metabolism; green chemistry; Green Chemistry Technology; Industrial production; lipase; Lipase - chemistry; Lipase - metabolism; Metal-organic frameworks; Metalorganic compounds; Organometallic Compounds - chemistry; physical adsorption; Physical Sciences; Precursors; Science & Technology; Silicon Dioxide - chemistry; Strategy; Sustainability; Warfarin; Warfarin - chemistry; Warfarin - metabolism; ACTIVATION; MOF; PERFORMANCE; lipase; TRYPSIN; PORCINE-PANCREATIC LIPASE; ADSORPTION; green chemistry; IMMOBILIZATION; metal-organic frameworks; warfarin; BIOCATALYSIS; ENZYMES; physical adsorption; SELECTIVITY
• ISSN: 0947-6539; 1521-3765; 1521-3765
• DOI: 10.1002/chem.201405252

A green and sustainable strategy synthesizes clinical medicine warfarin anticoagulant by using lipase‐supported metal–organic framework (MOF) bioreactors (see scheme). These findings may be beneficial for future studies in the industrial production of chemical, pharmaceutical, and agrochemical precursors. Green chemistry: A green and sustainable strategy synthesizes clinical medicine warfarin anticoagulant by using lipase‐supported metal–organic framework (MOF) bioreactors (see scheme). These findings may be beneficial for future studies in the industrial production of chemical, pharmaceutical, and agrochemical precursors.