Intellectual Impairment and Blood Lead Levels
To the Editor: In the light of the report on intellectual impairment and blood lead levels by Canfield et al. (April 17 issue), 1 we reanalyzed data from our prospective cohort study, 2 focusing on 48 children whose blood lead levels never exceeded 10 μg per deciliter at birth or at 6, 12, 18, 24, 5...
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Published in | The New England journal of medicine Vol. 349; no. 5; pp. 500 - 502 |
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Main Authors | , , , , , , |
Format | Journal Article |
Language | English |
Published |
United States
Massachusetts Medical Society
31.07.2003
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Subjects | |
Online Access | Get full text |
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Summary: | To the Editor:
In the light of the report on intellectual impairment and blood lead levels by Canfield et al. (April 17 issue),
1
we reanalyzed data from our prospective cohort study,
2
focusing on 48 children whose blood lead levels never exceeded 10 μg per deciliter at birth or at 6, 12, 18, 24, 57, or 120 months. The IQ at 120 months was inversely related to the lead level at 24 months with adjustment for covariates (P=0.03). Nonparametric smoothing analyses suggested that the inverse association persisted at blood lead levels below 5 μg per deciliter.
3
The blood lead coefficient (–1.56) . . . |
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ISSN: | 0028-4793 1533-4406 |
DOI: | 10.1056/NEJM200307313490515 |