Could titin have a role in strain-induced injuries

• Published in: Journal of sport and health science Vol. 6; no. 2; pp. 143 - 144
• Main Authors: Perrin, Craig, Nosaka, Kazunori, Steele, James
• Format: Journal Article
• Language: English
• Published: China Elsevier B.V 01.06.2017; School of Sport, Health and Social Sciences, Southampton Solent University Ringgold Standard Institution, Southampton, SO140YN, UK%School of Exercise and Health Sciences, Edith Cowan University, Joondalup, WA 6027, Australia; Shanghai University of Sport; Elsevier
• Subjects: Special issue; 力曲线; 应变诱导; 损伤机制; 最佳长度; 最大变形; 肌原纤维; 肌联蛋白; 肌肉纤维
• ISSN: 2095-2546; 2213-2961; 2213-2961
• DOI: 10.1016/j.jshs.2017.03.003

It has been known for some time that strain injuries occur through the excessive lengthening of a muscle. However, the precise mechanism for strain injury remains elusive and has been the subject of recent debate in the Journal of Sport and Health Science, but it seems sensible to consider mechanisms at the level of the muscle fiber. It was previously believed that damage was the result of non-uniform stretching of sarcomeres on the descending limb of the length-tension curve, with the weakest sarcomeres undergoing the greatest deformation and ultimately damaging the myofibril This non-uniform length- ening was also believed to explain the residual force enhance- ment observed during lengthening contractions, as the rapid lengthening of some sareomeres gives rise to passive tension whilst allowing the remaining sarcomeres to operate closer to their optimal length.