A One Health Perspective on Salmonella enterica Serovar Infantis, an Emerging Human Multidrug-Resistant Pathogen

• Published in: Emerging infectious diseases Vol. 30; no. 4; pp. 701 - 710
• Main Authors: Mattock, Jennifer, Chattaway, Marie Anne, Hartman, Hassan, Dallman, Timothy J, Smith, Anthony M, Keddy, Karen, Petrovska, Liljana, Manners, Emma J, Duze, Sanelisiwe T, Smouse, Shannon, Tau, Nomsa, Timme, Ruth, Baker, Dave J, Mather, Alison E, Wain, John, Langridge, Gemma C
• Format: Journal Article
• Language: English
• Published: United States U.S. National Center for Infectious Diseases 01.04.2024; Centers for Disease Control and Prevention
• Subjects: A One Health on; Analysis; Animal human relations; Animals; Anti-Bacterial Agents - pharmacology; antimicrobial resistance; bacteria; Contamination; Disease transmission; Drug resistance in microorganisms; Drug Resistance, Multiple, Bacterial - genetics; eBG31; Ethics; Feeds; Food; Genetic aspects; Genomes; Genomics; Health aspects; Humans; Infections; multidrug resistance; One Health; Pathogens; pESI; Phylogeny; Population; Population structure; Poultry; Prevention; Public health; Risk factors; Salmonella; Salmonella - genetics; Salmonella enterica; Salmonella enterica serovar Infantis; Salmonella food poisoning; Serogroup; serovar Infantis, an Emerging Human Multidrug-Resistant Pathogen; Surveillance; Tetracycline; Tetracyclines; United States; South America; South Africa; United Kingdom; Asia; North America; Ecuador; United Kingdom > UK; United States > US; Europe; Japan; Switzerland; multidrug resistance; bacteria; Salmonella enterica serovar Infantis; antimicrobial resistance; eBG31; pESI; One Health
• ISSN: 1080-6040; 1080-6059
• DOI: 10.3201/eid3004.231031

Salmonella enterica serovar Infantis presents an ever-increasing threat to public health because of its spread throughout many countries and association with high levels of antimicrobial resistance (AMR). We analyzed whole-genome sequences of 5,284 Salmonella Infantis strains from 74 countries, isolated during 1989-2020 from a wide variety of human, animal, and food sources, to compare genetic phylogeny, AMR determinants, and plasmid presence. The global Salmonella Infantis population structure diverged into 3 clusters: a North American cluster, a European cluster, and a global cluster. The levels of AMR varied by Salmonella Infantis cluster and by isolation source; 73% of poultry isolates were multidrug resistant, compared with 35% of human isolates. This finding correlated with the presence of the pESI megaplasmid; 71% of poultry isolates contained pESI, compared with 32% of human isolates. This study provides key information for public health teams engaged in reducing the spread of this pathogen.