硫酸镁联合小剂量阿司匹林治疗妊娠期高血压病的疗效观察
目的：探讨硫酸镁联合小剂量阿司匹林治疗妊娠期高血压病的临床疗效。方法：选择2014年8月—2015年8月收治的妊娠期高血压病患者100例,按随机数字表法对照组和观察组,每组各50例。对照组患者静脉滴注25%硫酸镁,1日20 g,滴速1~1.5 g/h;观察组患者在对照组治疗的基础上口服阿司匹林,1日50 mg。治疗3 d后,观察2组疗效、相关实验室指标及不良反应发生情况。结果：观察组患者的总有效率为94.00%（47/50）,明显高于对照组的60.00%（30/50）,差异有统计学意义（P〈0.05）;治疗后,观察组患者血液黏稠度、红细胞压积、尿蛋白量、脐动脉血流速度峰谷比、脐动脉血流阻力指数...
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| Published in | 中国医院用药评价与分析 Vol. 16; no. 6; pp. 749 - 751 |
|---|---|
| Main Author | |
| Format | Journal Article |
| Language | Chinese |
| Published |
江西省泰和县人民医院妇产科,江西泰和,343700
2016
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| Subjects | |
| Online Access | Get full text |
| ISSN | 1672-2124 |
| DOI | 10.14009/j.issn.1672-2124.2016.06.009 |
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| Abstract | 目的：探讨硫酸镁联合小剂量阿司匹林治疗妊娠期高血压病的临床疗效。方法：选择2014年8月—2015年8月收治的妊娠期高血压病患者100例,按随机数字表法对照组和观察组,每组各50例。对照组患者静脉滴注25%硫酸镁,1日20 g,滴速1~1.5 g/h;观察组患者在对照组治疗的基础上口服阿司匹林,1日50 mg。治疗3 d后,观察2组疗效、相关实验室指标及不良反应发生情况。结果：观察组患者的总有效率为94.00%（47/50）,明显高于对照组的60.00%（30/50）,差异有统计学意义（P〈0.05）;治疗后,观察组患者血液黏稠度、红细胞压积、尿蛋白量、脐动脉血流速度峰谷比、脐动脉血流阻力指数均较治疗前有明显改善,且改善程度明显优于对照组,差异均有统计学意义（P〈0.05）;观察组患者不良反应发生率为16.00%（8/50）,明显低于对照组的44.00%（22/50）,差异有统计学意义（P〈0.05）。结论：硫硫酸镁联合小剂量阿司匹林治疗妊娠期高血压病效果较好,可有效改善患者临床症状,且安全性较高,值得临床推广。 |
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| AbstractList | 目的：探讨硫酸镁联合小剂量阿司匹林治疗妊娠期高血压病的临床疗效。方法：选择2014年8月—2015年8月收治的妊娠期高血压病患者100例,按随机数字表法对照组和观察组,每组各50例。对照组患者静脉滴注25%硫酸镁,1日20 g,滴速1~1.5 g/h;观察组患者在对照组治疗的基础上口服阿司匹林,1日50 mg。治疗3 d后,观察2组疗效、相关实验室指标及不良反应发生情况。结果：观察组患者的总有效率为94.00%（47/50）,明显高于对照组的60.00%（30/50）,差异有统计学意义（P〈0.05）;治疗后,观察组患者血液黏稠度、红细胞压积、尿蛋白量、脐动脉血流速度峰谷比、脐动脉血流阻力指数均较治疗前有明显改善,且改善程度明显优于对照组,差异均有统计学意义（P〈0.05）;观察组患者不良反应发生率为16.00%（8/50）,明显低于对照组的44.00%（22/50）,差异有统计学意义（P〈0.05）。结论：硫硫酸镁联合小剂量阿司匹林治疗妊娠期高血压病效果较好,可有效改善患者临床症状,且安全性较高,值得临床推广。 R971+.1; 目的：探讨硫酸镁联合小剂量阿司匹林治疗妊娠期高血压病的临床疗效。方法：选择2014年8月—2015年8月收治的妊娠期高血压病患者100例，按随机数字表法对照组和观察组，每组各50例。对照组患者静脉滴注25％硫酸镁，1日20 g，滴速1～1．5 g／h；观察组患者在对照组治疗的基础上口服阿司匹林，1日50 mg。治疗3 d后，观察2组疗效、相关实验室指标及不良反应发生情况。结果：观察组患者的总有效率为94．00％（47／50），明显高于对照组的60．00％（30／50），差异有统计学意义（ P＜0．05）；治疗后，观察组患者血液黏稠度、红细胞压积、尿蛋白量、脐动脉血流速度峰谷比、脐动脉血流阻力指数均较治疗前有明显改善，且改善程度明显优于对照组，差异均有统计学意义（P＜0．05）；观察组患者不良反应发生率为16．00％（8／50），明显低于对照组的44．00％（22／50），差异有统计学意义（P＜0．05）。结论：硫硫酸镁联合小剂量阿司匹林治疗妊娠期高血压病效果较好，可有效改善患者临床症状，且安全性较高，值得临床推广。 |
| Abstract_FL | OBJECTIVE:To probe into the clinical efficacy of magnesium sulfate combined with low-dose aspirin in treatment of pregnancy-induced hypertension.METHODS:100 patients with pregnancy-induced hypertension admitted from Aug.2014 to Aug.2015 were selected to be divided into control group and observation group via the random number table , with 50 cases in each .The control group were treated with 25%intravenous infusion of magnesium sulfate in 1-1.5 g per hour, 20 g for a day;the observation group additionally received oral aspirin based on the control group , 50 mg for a day. After treatment of 3 d, the efficacy, related laboratory indicators and adverse drug reactions in two groups were observed . RESULTS:The total effective rate of observation group was 94.00%(47/50), significantly higher than that in the control group 60.00%(30/50), the difference was statistically significant ( P <0.05).After treatment, the blood viscosity, hematocrit , urinary protein excretion , peak-to-valley ratio of umbilical artery blood flow velocity and vascular resistance indicators of umbilical artery in observation group had been significantly improved compared with before treatment , and the improvement degree was better than that of control group , with statistically significant difference (P<0.05).The incidence of adverse drug reactions was 16.00%(8/50), significantly lower than that of control group 44.00%(22/50), with statistically significant difference ( P<0.05 ) .CONCLUSIONS: The effects of magnesium sulfate combined with low-dose aspirin in treatment of pregnancy-induced hypertension is remarkable , which can significantly improve the clinical symptoms in patients with high safety .It is worthy of clinical application and promotion . |
| Author | 张志娟 罗珍华 彭南燕 |
| AuthorAffiliation | 江西省泰和县人民医院妇产科,江西泰和343700 |
| AuthorAffiliation_xml | – name: 江西省泰和县人民医院妇产科,江西泰和,343700 |
| Author_FL | ZHANG Zhijuan LUO Zhenhua PENG Nanyan |
| Author_FL_xml | – sequence: 1 fullname: ZHANG Zhijuan – sequence: 2 fullname: LUO Zhenhua – sequence: 3 fullname: PENG Nanyan |
| Author_xml | – sequence: 1 fullname: 张志娟 罗珍华 彭南燕 |
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| Keywords | Hypertension Pregnancy 硫酸镁 妊娠期 Magnesium sulfate Aspirin 阿司匹林 高血压病 |
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| Notes | OBJECTIVE：To probe into the clinical efficacy of magnesium sulfate combined with low-dose aspirin in treatment of pregnancy-induced hypertension.METHODS：100 patients with pregnancy-induced hypertension admitted from Aug.2014 to Aug.2015 were selected to be divided into control group and observation group via the random number table , with 50 cases in each .The control group were treated with 25%intravenous infusion of magnesium sulfate in 1-1.5 g per hour, 20 g for a day;the observation group additionally received oral aspirin based on the control group , 50 mg for a day. After treatment of 3 d, the efficacy, related laboratory indicators and adverse drug reactions in two groups were observed . RESULTS：The total effective rate of observation group was 94.00%（47/50）, significantly higher than that in the control group 60.00%（30/50）, the difference was statistically significant （ P 〈0.05）.After treatment, the blood viscosity, hematocrit , urinary protein excretion , peak-to-valley ratio of umbilical artery bloo |
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| Snippet | 目的：探讨硫酸镁联合小剂量阿司匹林治疗妊娠期高血压病的临床疗效。方法：选择2014年8月—2015年8月收治的妊娠期高血压病患者100例,按随机数字表法对照组和观察组,每组各50例。对照组患者静脉滴注25%硫酸镁,1日20 g,滴速1~1.5 g/h;观察组患者在对照组治疗的基础上口服阿司匹林,1日50 mg。治疗3... R971+.1; 目的：探讨硫酸镁联合小剂量阿司匹林治疗妊娠期高血压病的临床疗效。方法：选择2014年8月—2015年8月收治的妊娠期高血压病患者100例，按随机数字表法对照组和观察组，每组各50例。对照组患者静脉滴注25％硫酸镁，1日20 g，滴速1～1．5... |
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| SubjectTerms | 妊娠期 硫酸镁 阿司匹林 高血压病 |
| Title | 硫酸镁联合小剂量阿司匹林治疗妊娠期高血压病的疗效观察 |
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