硫酸镁联合小剂量阿司匹林治疗妊娠期高血压病的疗效观察

目的：探讨硫酸镁联合小剂量阿司匹林治疗妊娠期高血压病的临床疗效。方法：选择2014年8月—2015年8月收治的妊娠期高血压病患者100例,按随机数字表法对照组和观察组,每组各50例。对照组患者静脉滴注25%硫酸镁,1日20 g,滴速1~1.5 g/h;观察组患者在对照组治疗的基础上口服阿司匹林,1日50 mg。治疗3 d后,观察2组疗效、相关实验室指标及不良反应发生情况。结果：观察组患者的总有效率为94.00%（47/50）,明显高于对照组的60.00%（30/50）,差异有统计学意义（P〈0.05）;治疗后,观察组患者血液黏稠度、红细胞压积、尿蛋白量、脐动脉血流速度峰谷比、脐动脉血流阻力指数...

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Published in中国医院用药评价与分析 Vol. 16; no. 6; pp. 749 - 751
Main Author 张志娟 罗珍华 彭南燕
Format Journal Article
LanguageChinese
Published 江西省泰和县人民医院妇产科,江西泰和,343700 2016
Subjects
妊娠期
硫酸镁
阿司匹林
高血压病
Hypertension
Pregnancy
硫酸镁
妊娠期
Magnesium sulfate
Aspirin
阿司匹林
高血压病
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ISSN1672-2124
DOI10.14009/j.issn.1672-2124.2016.06.009

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Summary:目的：探讨硫酸镁联合小剂量阿司匹林治疗妊娠期高血压病的临床疗效。方法：选择2014年8月—2015年8月收治的妊娠期高血压病患者100例,按随机数字表法对照组和观察组,每组各50例。对照组患者静脉滴注25%硫酸镁,1日20 g,滴速1~1.5 g/h;观察组患者在对照组治疗的基础上口服阿司匹林,1日50 mg。治疗3 d后,观察2组疗效、相关实验室指标及不良反应发生情况。结果：观察组患者的总有效率为94.00%（47/50）,明显高于对照组的60.00%（30/50）,差异有统计学意义（P〈0.05）;治疗后,观察组患者血液黏稠度、红细胞压积、尿蛋白量、脐动脉血流速度峰谷比、脐动脉血流阻力指数均较治疗前有明显改善,且改善程度明显优于对照组,差异均有统计学意义（P〈0.05）;观察组患者不良反应发生率为16.00%（8/50）,明显低于对照组的44.00%（22/50）,差异有统计学意义（P〈0.05）。结论：硫硫酸镁联合小剂量阿司匹林治疗妊娠期高血压病效果较好,可有效改善患者临床症状,且安全性较高,值得临床推广。
Bibliography:OBJECTIVE：To probe into the clinical efficacy of magnesium sulfate combined with low-dose aspirin in treatment of pregnancy-induced hypertension.METHODS：100 patients with pregnancy-induced hypertension admitted from Aug.2014 to Aug.2015 were selected to be divided into control group and observation group via the random number table , with 50 cases in each .The control group were treated with 25%intravenous infusion of magnesium sulfate in 1-1.5 g per hour, 20 g for a day;the observation group additionally received oral aspirin based on the control group , 50 mg for a day. After treatment of 3 d, the efficacy, related laboratory indicators and adverse drug reactions in two groups were observed . RESULTS：The total effective rate of observation group was 94.00%（47/50）, significantly higher than that in the control group 60.00%（30/50）, the difference was statistically significant （ P 〈0.05）.After treatment, the blood viscosity, hematocrit , urinary protein excretion , peak-to-valley ratio of umbilical artery bloo
ISSN:1672-2124
DOI:10.14009/j.issn.1672-2124.2016.06.009